Genetic Code: Introducing Pyrrolysine Michael Ibba, Dieter Söll  Current Biology  Volume 12, Issue 13, Pages R464-R466 (July 2002) DOI: 10.1016/S0960-9822(02)00947-8

Figure 1 The structures of pyrrolysine and lysine. X indicates a methyl, ammonium or hydroxyl group. Current Biology 2002 12, R464-R466DOI: (10.1016/S0960-9822(02)00947-8)

Figure 2 Putative scheme for the co-translational insertion of pyrrolysine at amber codons. An amber suppressing tRNA (tRNACUA) is first charged with lysine by PylS to give Lys-tRNACUA. Lys-tRNACUA undergoes pre-translational modification to produce Pyl-tRNACUA which is then used for the translation on in-frame amber codons during ribosomal protein synthesis. Current Biology 2002 12, R464-R466DOI: (10.1016/S0960-9822(02)00947-8)