Clara cell 16-kd protein downregulates TH2 differentiation of human naive neonatal T cells Sofi Johansson, MSc, Göran Wennergren, MD, PhD, Nils Åberg,

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Presentation transcript:

Clara cell 16-kd protein downregulates TH2 differentiation of human naive neonatal T cells Sofi Johansson, MSc, Göran Wennergren, MD, PhD, Nils Åberg, MD, PhD, Anna Rudin, MD, PhD Journal of Allergy and Clinical Immunology Volume 120, Issue 2, Pages 308-314 (August 2007) DOI: 10.1016/j.jaci.2007.03.021 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Plasma concentrations of CC16 in children in cord blood (n = 49) and at 4 (n = 48), 18 (n = 54), and 36 (n = 54) months and in 20 adults (10 individuals with birch pollen allergy and 10 healthy control subjects). ∗∗∗P < .0001 (Wilcoxon signed-rank test and Mann-Whitney U test). Journal of Allergy and Clinical Immunology 2007 120, 308-314DOI: (10.1016/j.jaci.2007.03.021) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Naive T cells from cord blood were differentiated into TH2-deviated cells before stimulation with 1, 10, 30, and 100 ng/mL CC16 for 48 hours. The levels of IL-13 (A), IL-5 (B), and IL-10 (C) were measured in the supernatants by means of ELISA. Individual data from 6 different experiments are shown, and each individual is represented by a specific symbol. D, One representative flow cytometric experiment out of 6 showing results from intracellular staining of IFN-γ and IL-13 on day 10. Journal of Allergy and Clinical Immunology 2007 120, 308-314DOI: (10.1016/j.jaci.2007.03.021) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Monocyte-derived DCs were stimulated with birch allergen extract or birch allergen together with CC16. Thereafter, DCs were washed and cocultured with naive autologous CD4+ T cells. A, IL-13 and IL-5 levels determined by means of ELISA are summarized as box-and-whiskers graphs, with the box indicating median levels and interquartile range and the whiskers indicating the range (n = 7). B, Individual values of IL-13 and IL-5 from 7 individuals after stimulation with birch allergen alone or together with CC16. C, Effect of the control protein HSA on IL-13 and IL-5 production. ∗P < .05, ∗∗P < .01 (Friedman test followed by the Dunn multiple comparison test). Journal of Allergy and Clinical Immunology 2007 120, 308-314DOI: (10.1016/j.jaci.2007.03.021) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Monocyte-derived DCs were stimulated with birch allergen extract together with DP1 (A) or DP2 (B) antagonist for 24 hours. Thereafter, DCs were washed and cocultured with naive autologous CD4+ T cells. On day 10, production of IL-13 was analyzed by means of ELISA. Nine (Fig 4, A) and 6 (Fig 4, B) independent experiments are shown, and red lines in diamonds indicate individuals producing high levels of IL-13. Journal of Allergy and Clinical Immunology 2007 120, 308-314DOI: (10.1016/j.jaci.2007.03.021) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions