Chronology of Metastasis in Cutaneous Melanoma: Growth Rate Model Antonio Tejera-Vaquerizo, Eduardo Nagore, Juan J. Meléndez, Norberto López-Navarro, Antonio Martorell-Calatayud, Enrique Herrera- Acosta, Victor Traves, Carlos Guillén, Enrique Herrera-Ceballos  Journal of Investigative Dermatology  Volume 132, Issue 4, Pages 1215-1221 (April 2012) DOI: 10.1038/jid.2011.433 Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Basic theory of the model. The time of start of metastatic dissemination depends on the growth rate of the melanoma. Journal of Investigative Dermatology 2012 132, 1215-1221DOI: (10.1038/jid.2011.433) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Time of development versus growth rate of melanomas corresponding to the Hospital Virgen de la Victoria, Málaga. The dispersion chart shows fatal and nonfatal melanomas. The potential function representing the time of onset of metastatic dissemination (dashed line). Arrows: cases of fatal melanoma selected to calculate the model below which no more fatal cases were seen. Journal of Investigative Dermatology 2012 132, 1215-1221DOI: (10.1038/jid.2011.433) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Time of development versus growth rate of melanomas corresponding to the Instituto Valenciano de Oncología, Valencia. The dispersion chart shows fatal and nonfatal melanomas. The potential function representing the time of onset of metastatic dissemination (dashed line). Arrows: cases of fatal melanoma selected to calculate the model below which no more fatal cases were seen. Journal of Investigative Dermatology 2012 132, 1215-1221DOI: (10.1038/jid.2011.433) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions