Joline S. W. Lind, MBBS, Egbert F

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Fatal Interstitial Lung Disease After Erlotinib for Non-small Cell Lung Cancer Joline S.W. Lind, MBBS, Egbert F. Smit, MD, PhD, Katrien Grünberg, MD, PhD, Suresh Senan, MRCP, FRCR, PhD, Frank J. Lagerwaard, MD, PhD Journal of Thoracic Oncology Volume 3, Issue 9, Pages 1050-1053 (September 2008) DOI: 10.1097/JTO.0b013e318183a9f5 Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 A, Case 1:CT pulmonary angiography (CT-PA) showing a bilateral ground-glass attenuation pattern with alveolar consolidation. B, Case 1: Hematoxylin and eosin staining of the lung tissue at autopsy showing exudative phase of diffuse alveolar damage (DAD) with hyaline membranes lining the alveolar spaces (black arrows) and lymphocytic interstitial infiltrate (blue arrows). Journal of Thoracic Oncology 2008 3, 1050-1053DOI: (10.1097/JTO.0b013e318183a9f5) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 A, Case 2:High resolution CT scan (HRCT) showing pre-existent pulmonary fibrosis with traction bronchiectasis and new extensive bilateral ground-glass attenuation with bilateral pleural effusions. B, Case 2: Hematoxylin and eosin staining of the lung tissue at autopsy showing acute phase DAD (left panel) with hyaline membranes (black arrows), intraalveolar proteinaceous fluid (green arrow) and erythrocytes (*) and organizing phase DAD (right panels) with formation of intraalveolar fibroblast plugs called Masson bodies (upper right panel) and type 2 pneumocyte hyperplasia and focal squamous metaplasia (lower right panel). Journal of Thoracic Oncology 2008 3, 1050-1053DOI: (10.1097/JTO.0b013e318183a9f5) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions