Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect- induced anaphylaxis shows unique features versus other indolent SM

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Presentation transcript:

Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect- induced anaphylaxis shows unique features versus other indolent SM Iván Álvarez-Twose, MD, Roberta Zanotti, MD, David González-de-Olano, MD, Patrizia Bonadonna, MD, Arantza Vega, MD, Almudena Matito, MD, Laura Sánchez-Muñoz, MD, PhD, José Mário Morgado, MSc, Omar Perbellini, MD, Andrés García-Montero, PhD, Giovanna De Matteis, MD, Cristina Teodósio, MSc, Maurizio Rossini, MD, María Jara-Acevedo, MSc, Donatella Schena, MD, Andrea Mayado, PhD, Alberto Zamò, MD, Manuela Mollejo, MD, PhD, Paula Sánchez-López, MD, Nieves Cabañes, MD, Alberto Orfao, MD, PhD, Luis Escribano, MD, PhD Iván Álvarez-Twose, MD, Roberta Zanotti, MD, David González-de-Olano, MD, Patrizia Bonadonna, MD, Arantza Vega, MD, Almudena Matito, MD, Laura Sánchez-Muñoz, MD, PhD, José Mário Morgado, MSc, Omar Perbellini, MD, Andrés García- Montero, PhD, Giovanna De Matteis, MD, Cristina Teodósio, MSc, Maurizio Rossini, MD, María Jara-Acevedo, MSc, Donatella Schena, MD, Andrea Mayado, PhD, Alberto Zamò, MD, Manuela Mollejo, MD, PhD, Paula Sánchez-López, MD, Nieves Cabañes, MD, Alberto Orfao, MD, PhD, Luis Escribano, MD, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 2, Pages 520-528.e5 (February 2014) DOI: 10.1016/j.jaci.2013.06.020 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Distribution of clinical symptoms associated with the most severe MC-mediator release episode (A) and in between acute episodes (B) in patients with insectISMs− (n = 143) versus otherISMs− cases (n = 72) and ISMs+ patients (n = 56). Only clinical symptoms showing statistically significant differences (P < .05) among the different groups of patients are shown (A). GI, Gastrointestinal; NS, statistically not significant. Journal of Allergy and Clinical Immunology 2014 133, 520-528.e5DOI: (10.1016/j.jaci.2013.06.020) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Distribution of different triggers involved in acute MC-mediator release episodes in patients with insectISMs− (n = 143) (A), otherISMs− (n = 72) (B), ISMs+ (n = 56) (C), and nonclonal MCAS (n = 64) (D). Black boxes indicate the specific trigger(s) for MC-mediator release episodes involved in every case, and striped boxes represent those fish-triggered cases in which hypersensitivity to Anisakis simplex was found by CAP and/or skin tests. Journal of Allergy and Clinical Immunology 2014 133, 520-528.e5DOI: (10.1016/j.jaci.2013.06.020) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Distribution of different triggers involved in acute MC-mediator release episodes in patients with insectISMs− (n = 143) (A), otherISMs− (n = 72) (B), ISMs+ (n = 56) (C), and nonclonal MCAS (n = 64) (D). Black boxes indicate the specific trigger(s) for MC-mediator release episodes involved in every case, and striped boxes represent those fish-triggered cases in which hypersensitivity to Anisakis simplex was found by CAP and/or skin tests. Journal of Allergy and Clinical Immunology 2014 133, 520-528.e5DOI: (10.1016/j.jaci.2013.06.020) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Distribution of different triggers involved in acute MC-mediator release episodes in patients with insectISMs− (n = 143) (A), otherISMs− (n = 72) (B), ISMs+ (n = 56) (C), and nonclonal MCAS (n = 64) (D). Black boxes indicate the specific trigger(s) for MC-mediator release episodes involved in every case, and striped boxes represent those fish-triggered cases in which hypersensitivity to Anisakis simplex was found by CAP and/or skin tests. Journal of Allergy and Clinical Immunology 2014 133, 520-528.e5DOI: (10.1016/j.jaci.2013.06.020) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Distribution of different triggers involved in acute MC-mediator release episodes in patients with insectISMs− (n = 143) (A), otherISMs− (n = 72) (B), ISMs+ (n = 56) (C), and nonclonal MCAS (n = 64) (D). Black boxes indicate the specific trigger(s) for MC-mediator release episodes involved in every case, and striped boxes represent those fish-triggered cases in which hypersensitivity to Anisakis simplex was found by CAP and/or skin tests. Journal of Allergy and Clinical Immunology 2014 133, 520-528.e5DOI: (10.1016/j.jaci.2013.06.020) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions