Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall Hirotaka Nagashima,

Slides:

Advertisements

Similar presentations

Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects Hirotsugu Kurobe, MD, PhD, Yuki Matsuoka,

Advertisements

Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice Ryotaro Hashizume, MD, Aika Yamawaki-Ogata,

Robert J. Pitsch, MD, David J. Minion, MD, Margaret L

Endogenous superoxide dismutase activation by oral administration of riboflavin reduces abdominal aortic aneurysm formation in rats Zhenhai Yu, MD, Keisuke.

Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic.

Transglutaminase type 2 in human abdominal aortic aneurysm is a potential factor in the stabilization of extracellular matrix Sung Shin, MD, Yong-Pil.

Age-related trends in utilization and outcome of open and endovascular repair for abdominal aortic aneurysm in the United States, Margaret.

Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic.

Popliteal artery aneurysms differ from abdominal aortic aneurysms in cellular topography and inflammatory markers Rob Hurks, MD, PhD, Rogier H.J. Kropman,

Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model Jianping Dai, MD, PhD, Liliane.

Markers of instability in high-risk carotid plaques are reduced by statins Hagen Kunte, MD, Nicola Amberger, MD, Markus Alexander Busch, MD, MPH, Ralph-Ingo.

Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content Hazem Abdul-Hussien, MD, Roeland Hanemaaijer,

Controlled release of ascorbic acid from gelatin hydrogel attenuates abdominal aortic aneurysm formation in rat experimental abdominal aortic aneurysm.

Karen M. Newman, PhD, Jessie Jean-Claude, MD, Hong Li, MS, John V

Veysel Kutay, MD, Cevat Yakut, MD, Hasan Ekim, MD

Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats

Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats Keisuke Morimoto, MD, Tomomi Hasegawa,

Inducible nitric oxide synthase is present in human abdominal aortic aneurysm and promotes oxidative vascular injury Jian Zhang, MD, Jan Schmidt, MD,

A decade of change in abdominal aortic aneurysm repair in the United States: Have we improved outcomes equally between men and women? Ellen D. Dillavou,

In situ localization and quantification of seventy-two – kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta William D. McMillan,

Rat and human aortic smooth muscle cells display differing migration and matrix metalloproteinase activities in response to dexamethasone C. Pross, MD,

Murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta Zhenjie Liu, MD, PhD, Qiwei Wang,

Dennis R. Holmes, MD, William Wester, BA, Robert W

Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic.

Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells Qinxue Ding,

High prevalence of abdominal aortic aneurysms in brothers and sisters of patients despite a low prevalence in the population Anneli Linné, MD, David.

Cigarette smoking increases aortic dilatation without affecting matrix metalloproteinase- 9 and -12 expression in a modified mouse model of aneurysm formation

Jing Wen, MD, Peiyi Wang, MS, Sumona V. Smith, MD, Carolyn A

Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms Maggie Folkesson,

Intraobserver and interobserver variability and spatial differences in histologic examination of carotid endarterectomy specimens Willem E. Hellings,

The pathophysiology of abdominal aortic aneurysm growth: Corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal.

In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the.

Anders Wanhainen, MD, PhD, Torbjörn K

Markers of instability in high-risk carotid plaques are reduced by statins Hagen Kunte, MD, Nicola Amberger, MD, Markus Alexander Busch, MD, MPH, Ralph-Ingo.

A novel rat model of abdominal aortic aneurysm using a combination of intraluminal elastase infusion and extraluminal calcium chloride exposure Akiko.

Exploration of the mechanisms by which 3,4-benzopyrene promotes angiotensin II- induced abdominal aortic aneurysm formation in mice Kangting Ji, MD, Yong.

Comparison of cell-type-specific vs transmural aortic gene expression in experimental aneurysms Eiketsu Sho, MD, PhD, Mien Sho, MD, Hiroshi Nanjo, MD,

Accessory mitral valve tissue causing severe left ventricular outflow tract obstruction in an adult Yoshikazu Aoka, MD, Naoko Ishizuka, MD, PhD, Yasunari.

Increased ICAM-1 expression in aortic disease

Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose.

Journal of Vascular Surgery

Nontraumatic pseudoaneurysm of the proximal ulnar artery with eosinophilia Seishiro Sekino, MD, Hisato Takagi, MD, PhD, Takayoshi Kato, MD, Yukihiro Matsuno,

Aortic wall cell proliferation via basic fibroblast growth factor gene transfer limits progression of experimental abdominal aortic aneurysm Katsuyuki.

A new clinicopathological entity of IgG4-related inflammatory abdominal aortic aneurysm Satomi Kasashima, MD, PhD, Yoh Zen, MD, PhD, Atsuhiro Kawashima,

Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation Y. Akasaki, M.D., S. Matsuda,

Outcomes of an abdominal aortic aneurysm screening program

Morphologic characteristics of varicose veins: possible role of metalloproteinases Kenneth J Woodside, MD, Mingdao Hu, MD, Ann Burke, MS, Maki Murakami,

David K.W. Chew, MD, Michael S. Conte, MD, Raouf A. Khalil, MD, PhD

James M. Wong, MDa, Michelle A

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice Jing Wang, MD, PhD, Galina K. Sukhova, PhD,

Paul E. Norman, MD, Katrina Spilsbury, PhD, James B. Semmens, PhD

Simple renal cyst and abdominal aortic aneurysm

Trends in abdominal aortic aneurysm repair in the era of endovascular technology in Ontario Abdulmajeed Altoijry, MD, Muhammad Mamdani, PharmD, MA, MPH,

Metalloproteinase expression in venous aneurysms

Regarding “Endovascular repair of ruptured abdominal aortic aneurysms”

Development of a spontaneously beating vein by cardiomyocyte transplantation in the wall of the inferior vena cava in a rat: A pilot study Wangde Dai,

Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease Esther Martinez-Aguilar, MD,

Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia Giuseppe R Nigri, MD, PhD, Sylvie.

The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms David A. Bigatel, MD, James R. Elmore, MD, David.

Molecular diagnosis of nonaneurysmal infectious aortitis

Regarding “Lunar cycles and abdominal aortic aneurysm rupture”

Journal of Vascular Surgery

Inflammation in the walls of asymptomatic abdominal aortic aneurysms is not associated with increased metabolic activity detectable by 18-fluorodeoxglucose.

Wanfen Xiong, MD, PhD, Rebecca Knispel, BS, Jason Mactaggart, MD, B

Activation of transglutaminase type 2 for aortic wall protection in a rat abdominal aortic aneurysm formation Takashi Munezane, MD, Tomomi Hasegawa,

A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: A role for matrix metalloproteinase 9 and 2 Indranil Sinha, BA, Siddharth.

Cysteine protease activity in the wall of abdominal aortic aneurysms

Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis.

A novel rat model of abdominal aortic aneurysm using a combination of intraluminal elastase infusion and extraluminal calcium chloride exposure Akiko.

Matthew Thompson, MD, Peter Holt, PhD, Ian Loftus, MD, Thomas L

Presentation transcript:

Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall Hirotaka Nagashima, MD, PhD, Yoshikazu Aoka, MD, Yasunari Sakomura, MD, PhD, Kenta Uto, MD, Akiko Sakuta, MD, Shigeyuki Aomi, MD, PhD, Hiromi Kurosawa, MD, PhD, Nobuhisa Hagiwara, MD, PhD, Masatoshi Kawana, MD, PhD, Hiroshi Kasanuki, MD, PhD Journal of Vascular Surgery Volume 39, Issue 2, Pages 447-453 (February 2004) DOI: 10.1016/j.jvs.2003.07.005

Fig 1 Trapidil significantly reduced the levels of active MMP-2 in a concentration-dependent manner in organ cultures (A) but did not alter that of MMP-9 (B). Value of the trend test, P < .001. Journal of Vascular Surgery 2004 39, 447-453DOI: (10.1016/j.jvs.2003.07.005)

Fig 2 Effect of trapidil (10 μmol/L), anti-CD154 (100 μmol/L), or aspirin (10 μmol/L) on active MMP-2 production in AAA tissues. Both trapidil and anti-CD154 antibody inhibited MMP-2 production. *P < .01 vs lane 1. Journal of Vascular Surgery 2004 39, 447-453DOI: (10.1016/j.jvs.2003.07.005)

Fig 3 Representative pattern of semiquantitative RT-PCR for MMP-2 and MMP-9. Trapidil suppressed MMP-2 mRNA expression but not MMP-9 mRNA expression. Journal of Vascular Surgery 2004 39, 447-453DOI: (10.1016/j.jvs.2003.07.005)

Fig 4 Immunohistochemical analysis. A, Hematoxylin and eosin staining. AAA tissue contains numerous inflammatory cells (magnification, 40×). B, MMP-2 is positive on macrophages (magnification, 400×). C and D, MMP-9 is produced by macrophages, a lot of neutrophils circulating in blood vessels, or neutrophils infiltrating into the aortic wall tissue (magnification, 400×). Journal of Vascular Surgery 2004 39, 447-453DOI: (10.1016/j.jvs.2003.07.005)

Fig 5 Immunostaining for CD40. A, Low magnification (40×). B, High magnification (400×). CD40 was expressed on B cells, T cells, and macrophages. Neutrophils did not express CD40. Journal of Vascular Surgery 2004 39, 447-453DOI: (10.1016/j.jvs.2003.07.005)

Fig 6 Schematic hypothesis for the inhibitory effect of trapidil on AAA formation and progression. Journal of Vascular Surgery 2004 39, 447-453DOI: (10.1016/j.jvs.2003.07.005)