Supplementary Figure 1. Pathological signatures of acute severe blast injury to lung using the shock tube settings of the present study. Hematoxylin &

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Supplementary Figure 1. Pathological signatures of acute severe blast injury to lung using the shock tube settings of the present study. Hematoxylin & eosin. A,B: Acute hemorrhagic infiltration in a portion of a lobe (A), including areas of hemorrhagic consolidation with near-effacement of alveolar spaces (lung hepatosis) indicated with arrows. Areas retaining relatively normal lung histology are shown with asterisks. Area of consolidation is shown at greater magnification in (B). C, D: Areas of acute severe interstitial congestion (C) coexisting with areas of preservation of lung histology (D) in a case different from that illustrated in (A, B). Even in (C), alveolar structure is largely maintained. Asterisks indicate the presence of alveolar sacs. E, F: In less damaged tissues, as in medial lobe from the same case as (A, B), there are congested areas (bottom tissue in [E]) alternating with areas of hyperventilation (bracketed in [E] and further magnified in [F]). Scale bars: A, 500 µm; B-D, 50 µm; E, 200 µm.