Kinetics and symmetry of divisions of hematopoietic stem cells Anthony D. Ho  Experimental Hematology  Volume 33, Issue 1, Pages 1-8 (January 2005) DOI: 10.1016/j.exphem.2004.09.004 Copyright © 2005 International Society for Experimental Hematology Terms and Conditions

Figure 1 Types of asymmetric divisions during development of the nervous system in Drosophila. Experimental Hematology 2005 33, 1-8DOI: (10.1016/j.exphem.2004.09.004) Copyright © 2005 International Society for Experimental Hematology Terms and Conditions

Figure 2 Stem cells divide to self-renew as well as to produce differentiating daughter cells. Most stem cells, including hematopoietic stem cells, divide slowly, whereas differentiating cells are derived from a lineage committed, rapidly dividing daughter cell. After transplantation, e.g., the stem cells divide symmetrically to produce identical, self-renewing daughter cells to replenish the stem cell pool (transient amplifying pool). Some of these cells then divide asymmetrically after one or more self-renewing, symmetric divisions to give rise to one identical stem cell and another precursor cell that divides rapidly and symmetrically to give rise to committed progenitors. Experimental Hematology 2005 33, 1-8DOI: (10.1016/j.exphem.2004.09.004) Copyright © 2005 International Society for Experimental Hematology Terms and Conditions