Study of circulating hepcidin in association with iron excess, metabolic syndrome, and BMP-6 expression in granulosa cells in women with polycystic ovary.

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Presentation transcript:

Study of circulating hepcidin in association with iron excess, metabolic syndrome, and BMP-6 expression in granulosa cells in women with polycystic ovary syndrome Ji Won Kim, M.D., Ph.D., Kyung Min Kang, M.Sc., Tae Ki Yoon, M.D., Ph.D., Sung Han Shim, Ph.D., Woo Sik Lee, M.D., Ph.D. Fertility and Sterility Volume 102, Issue 2, Pages 548-554.e2 (August 2014) DOI: 10.1016/j.fertnstert.2014.04.031 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The average expression levels of bone morphogenetic protein 6 (BMP-6) in the luteinized granulosa cells (GCs) from nine polycystic ovary syndrome (PCOS) women and five non-PCOS (control) women. The BMP-6 expression level was higher in the GCs from PCOS patients compared with control subjects, although there was no statistical significance (P=.08). Fertility and Sterility 2014 102, 548-554.e2DOI: (10.1016/j.fertnstert.2014.04.031) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Correlations of iron parameters with circulating hepcidin. (A) Ferritin, (B) iron, (C) total iron binding capacity (TIBC), and (D) transferrin saturation. The broken horizontal and vertical lines in each figure represent the upper normal limit. Fertility and Sterility 2014 102, 548-554.e2DOI: (10.1016/j.fertnstert.2014.04.031) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions