Edwin A. Bronsky, MD, Howard Druce, MD, Steven R. Findlay, MD, Frank C

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Presentation transcript:

A clinical trial of ipratropium bromide nasal spray in patients with perennial nonallergic rhinitis  Edwin A. Bronsky, MD, Howard Druce, MD, Steven R. Findlay, MD, Frank C. Hampel, MD, Harold Kaiser, MD, Paul Ratner, MD, Martin D. Valentine, MD, Chester C. Wood, MD  Journal of Allergy and Clinical Immunology  Volume 95, Issue 5, Pages 1117-1122 (May 1995) DOI: 10.1016/S0091-6749(95)70215-6 Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Adjusted mean change in rhinorrhea during 8 weeks of treatment. The combined measure was a weighted average of duration and severity. Journal of Allergy and Clinical Immunology 1995 95, 1117-1122DOI: (10.1016/S0091-6749(95)70215-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Adjusted mean change in rhinorrhea during 8 weeks of treatment. The combined measure was a weighted average of duration and severity. Journal of Allergy and Clinical Immunology 1995 95, 1117-1122DOI: (10.1016/S0091-6749(95)70215-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Adjusted mean change in rhinorrhea during 8 weeks of treatment. The combined measure was a weighted average of duration and severity. Journal of Allergy and Clinical Immunology 1995 95, 1117-1122DOI: (10.1016/S0091-6749(95)70215-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Proportion of patients with symptoms who believed the trial medication provided either "good" or "excellent" control of rhinorrhea. Journal of Allergy and Clinical Immunology 1995 95, 1117-1122DOI: (10.1016/S0091-6749(95)70215-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Reduction in the degree to which rhinorrhea interfered with daily activities and moods; percentage of patients experiencing a significant improvement in quality of life (i.e., interference none or title of the time). Journal of Allergy and Clinical Immunology 1995 95, 1117-1122DOI: (10.1016/S0091-6749(95)70215-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Absence of nasal rebound on cessation of treatment with ipratropium bromide nasal spray. Journal of Allergy and Clinical Immunology 1995 95, 1117-1122DOI: (10.1016/S0091-6749(95)70215-6) Copyright © 1995 Mosby, Inc. Terms and Conditions