Intravenous delivery of reovirus to primary and secondary brain tumors

Slides:



Advertisements
Similar presentations
Fig. 1. TP is highly expressed in myeloma.
Advertisements

Examples of functional imaging biomarkers in two DCA responders
Fig. 4. Primary human metastatic melanomas contain CCL21-expressing LECs, and expression of VEGFC positively correlates with hallmarks of tumor inflammation.
Fig. 2. LUM015 fluorescently labels tumor cells in mouse models of STS and breast cancer. LUM015 fluorescently labels tumor cells in mouse models of STS.
Nat. Rev. Clin. Oncol. doi: /nrclinonc
Fig. 3. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures.
Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.
PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.
Fig. 3. Obese IFN-γ−/− mice develop accelerated NAFLD with fibrosis.
Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating lymphocytes. Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating.
Fig. 6. Combinatorial VCPI and OV M1 treatment is efficacious in vivo and ex vivo. Combinatorial VCPI and OV M1 treatment is efficacious in vivo and ex.
Analysis of brain and spinal cord of treated Gaa−/− mice and controls
Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.
Fig. 4. Prion infectivity of skin samples from sCJD patients.
Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.
Fig. 4 Bone tissue formation within the Ti-mesh channels.
Fig. 2. GPC3 expression in normal and tumor tissues.
Fig. 5. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic mice. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic.
Fig. 5. Immunohistochemistry of the tumor microenvironment in GBM specimens before and after CART-EGFRvIII infusion. Immunohistochemistry of the tumor.
Fig. 1. Paclitaxel delays tumor growth and promotes infiltration of TIE2hi/VEGFhi macrophages and TMEM assembly. Paclitaxel delays tumor growth and promotes.
Expression of CD36 and psap in a TMA of human ovarian cancer patients
Fig. 6. PVSRIPO oncolysate–pulsed DCs generate tumor antigen–specific CTL immunity in vitro. PVSRIPO oncolysate–pulsed DCs generate tumor antigen–specific.
Fig. 6. Effects of CD31-NP targeting in perfused human kidneys.
Figure 4 Detection of EBER+ cells in MS and control brains by in situ hybridization Detection of EBER+ cells in MS and control brains by in situ hybridization.
Fig. 4 Expression of cleaved caspase 3, PD-L1, and PD-1 in HGGs after reovirus treatment. Expression of cleaved caspase 3, PD-L1, and PD-1 in HGGs after.
Fig. 4. Specific versus nonspecific NP accumulation.
Fig. 4. Antitumor efficacy of ERY974 against various cancer types.
Fig. 1. CD31 is present throughout the human renal vasculature.
Fig. 1. Aberrant JNK pathway activation in mouse models of ALS and in spinal cord tissue from patients with sporadic ALS. Aberrant JNK pathway activation.
Immunofluorescence staining of virus-infected human placental explants
Fig. 5 Combination intravenous reovirus and checkpoint inhibition in an orthotopic syngeneic brain tumor model. Combination intravenous reovirus and checkpoint.
Expression of THBS2 in human PanIN tissue and PDAC tumor tissue
Fig. 1. Generation of the ΔEx50 mouse model.
Fig. 4. MATE1 transcription in RCC.
Fig. 2 In vitro assessment of hESC-RPE cell sheets.
Fig. 7 pDCs are critical for the maintenance of skin fibrosis and for the presence of CXCL4 in the skin. pDCs are critical for the maintenance of skin.
Fig. 1. Muscles of LAMA2 MD patients and dyW/dyW mice contain high amounts of laminin-α4 and show deficits in BM. Muscles of LAMA2 MD patients and dyW/dyW.
Fig. 5 Hypoxic tumors from obese mice associate with increased production of IL-6 by adipocytes and myeloid cells. Hypoxic tumors from obese mice associate.
Representative CT and PET/CT images of three patients with NSCLCs
Fig. 5 EGFR mutation status of patients with NSCLC, detected by histological examination and ARMS PCR. EGFR mutation status of patients with NSCLC, detected.
Fig. 7. KIF11 informs patient prognosis, and targeting improves survival in a preclinical model. KIF11 informs patient prognosis, and targeting improves.
Fig. 7. NPs accumulate at sites of vascular obstruction.
Christina I. Selinger, PhD, Wendy A
Fig. 5 Local gel scaffold for T cell memory response.
Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.
Fig. 4 TNF-α up-regulates Fas/Fap-1 expression to promote IL-1RA–sEV release in murine MSCs. TNF-α up-regulates Fas/Fap-1 expression to promote IL-1RA–sEV.
Fig. 7. NAC in breast cancer patients promotes TMEM assembly and increased MENAINV expression. NAC in breast cancer patients promotes TMEM assembly and.
PAAND is driven by local inflammasome activation and IL-1β production
Fig. 4. Features of PH in LLC1 lung tumor mice.
Fig. 1 CSPG4 is expressed in GBM specimens and GBM-NS and associated with more aggressive disease. CSPG4 is expressed in GBM specimens and GBM-NS and associated.
Fig F-FGln shows uptake in human gliomas undergoing progression.
Fig. 3 CSF1 is expressed in human melanoma.
Fig. 2 LAEs are characterized by vascular dysfunction, loss of endothelial perfusion and permeability, and perivascular hypoxia. LAEs are characterized.
Fig. 6 Photoreceptor cell survival in the RCS rat retina after transplantation with hESC-RPE cell sheets. Photoreceptor cell survival in the RCS rat retina.
Fig. 2. Cellular response to FolamiRs in vitro.
Fig. 1. Specificity of FolamiR uptake in cancer cells in culture.
Correlation of reovirus RNA/protein with proliferating tumor cells
Fig. 7 Transient immunosuppression (4 weeks) supports long-term graft survival and is associated with progressive decrease in spinal regional inflammatory.
Fig. 1 ZIKV RNA in blood and tissues.
Fig. 2. Clinically actionable somatic genomic alterations in various tumor types. Clinically actionable somatic genomic alterations in various tumor types.
Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.
Fig. 1 IDH3α expression is elevated in human-derived gliomas.
Fig. 4. Paclitaxel promotes the expression of invasive isoforms of MENA in the primary breast cancer microenvironment. Paclitaxel promotes the expression.
MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting Sox2. MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting.
TDP1 and TOP1 protein levels vary widely in colorectal cancer (CRC) patient samples. TDP1 and TOP1 protein levels vary widely in colorectal cancer (CRC)
Targeting p53-dependent stem cell loss for intestinal chemoprotection
Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.
Fig. 2. Col IV–Ac2-26 NPs increase subendothelial collagen in Ldlr−/− mice with established atherosclerosis. Col IV–Ac2-26 NPs increase subendothelial.
Detection of microcalcifications in 4T1 mammary tumors and human breast tumor tissue. Detection of microcalcifications in 4T1 mammary tumors and human.
Fig. 4 In situ mapping of human patient breast cancer and stroma.
Presentation transcript:

Fig. 1 Intravenous delivery of reovirus to primary and secondary brain tumors. Intravenous delivery of reovirus to primary and secondary brain tumors. (A) Representative immunohistochemistry (IHC) and in situ hybridization (ISH) trial and control patient tumor sections stained for reovirus σ3 protein (brown, top) and reovirus RNA (blue, bottom). The “control breast met” is a metastasis to the brain from a breast cancer primary. Arrows point to examples of positive cells/positive areas of tissue. Scale bars, 20 μm. HGG, high-grade glioma. (B) Trial and control patient tumor immunogold-TEM images for reovirus σ3 protein (arrows). CRC, colorectal cancer. Scale bars, 200 nm. (C) Quantitative reverse transcription polymerase chain reaction for reovirus σ3 gene, using whole tumor RNA. Data indicate femtograms (fg) reovirus RNA per microgram of whole tumor RNA. Histogram shows the mean of triplicate samples, and error bars indicate SD. (D) Representative immunofluorescence (IF) of trial patient tumor sections showing staining for reovirus RNA (blue), reovirus σ3 protein (red), and their coexpression (yellow). Scale bars, 80 μm. Adel Samson et al., Sci Transl Med 2018;10:eaam7577 Published by AAAS