Intravenous delivery of reovirus to primary and secondary brain tumors

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Fig. 1 Intravenous delivery of reovirus to primary and secondary brain tumors. Intravenous delivery of reovirus to primary and secondary brain tumors. (A) Representative immunohistochemistry (IHC) and in situ hybridization (ISH) trial and control patient tumor sections stained for reovirus σ3 protein (brown, top) and reovirus RNA (blue, bottom). The “control breast met” is a metastasis to the brain from a breast cancer primary. Arrows point to examples of positive cells/positive areas of tissue. Scale bars, 20 μm. HGG, high-grade glioma. (B) Trial and control patient tumor immunogold-TEM images for reovirus σ3 protein (arrows). CRC, colorectal cancer. Scale bars, 200 nm. (C) Quantitative reverse transcription polymerase chain reaction for reovirus σ3 gene, using whole tumor RNA. Data indicate femtograms (fg) reovirus RNA per microgram of whole tumor RNA. Histogram shows the mean of triplicate samples, and error bars indicate SD. (D) Representative immunofluorescence (IF) of trial patient tumor sections showing staining for reovirus RNA (blue), reovirus σ3 protein (red), and their coexpression (yellow). Scale bars, 80 μm. Adel Samson et al., Sci Transl Med 2018;10:eaam7577 Published by AAAS