Introduction: Internal membranes compartmentalize the eukaryotic cell

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Presentation transcript:

Introduction: Internal membranes compartmentalize the eukaryotic cell An eukaryotic cell has internal membranes, which partition the cell into compartments. These membranes also participate in metabolism as many enzymes are built into membranes. The general structure of a biological membrane is a double layer of phospholipids and diverse proteins. Each type of membrane has a unique combination of lipids and proteins for its specific functions. For example, those in the membranes of mitochondria function in cellular respiration.

1. The nucleus: Contains the cell’s genetic library The nucleus contains most of the genes in an eukaryotic cell as it is the repository for genetic material. The nucleus is separated from the cytoplasm by a double membrane called nuclear envelope. It directs activities of the cell. The nuclear membrane contains pores that allow large macromolecules and particles to pass through. The nuclear membrane is maintaining the shape of the nucleus.

The nucleus contains “chromatin fiber” which is made up of DNA and proteins. When the cell prepares to divide, the chromatin fibers coil up and condensed to be seen as “chromosomes”. Each eukaryotic species has a characteristic number of chromosomes. - A typical human cell has 46 chromosomes, but sex cells or gametes (eggs and sperm) have only 23 chromosomes. The nucleus directs protein synthesis by synthesizing messenger RNA (mRNA). The mRNA travels to the cytoplasm and combines with ribosomes to translate its genetic message into the primary structure of a specific protein. Nucleolus is a dark region involved in production of ribosomes.

2. Ribosomes: build the cell’s proteins Ribosomes are RNA-protein complexes composed of two subunits (large and small) that join and attach to messenger RNA to carry out protein synthesis. So, it is the site of protein synthesis Ribosome assembly begins in the nucleolus and is completed in the cytoplasm

A)- The endoplasmic reticulum (ER) (intracellular highway) Largest internal membrane, Composed of Lipid bilayer Serves as a system of channels from the nucleus Functions in storage and secretion There are two types of ER those are different in structure and function. Smooth ER looks smooth because it lacks ( does not have ) ribosomes. Rough ER looks rough because ribosomes (bound ribosomes) are attached to its outside. Smooth Rough

The smooth ER: The rough ER: It is Smooth as it lacks the associated ribosomes. It is rich in enzymes and plays a role in metabolic processes. Its enzymes synthesize lipids (oils, phospholipids and steroids) including the sex hormones. Extensive in the liver, it helps in detoxifying drugs and poisons The rough ER: It is “rough” because of the associated ribosomes (sites of protein synthesis) It is especially abundant in those cells that secrete proteins such as digestive glands and antibody-producing cells. These secretory proteins are packaged in transport vesicles that carry them to their next stage.

B)- Golgi apparatus: finishes, sorts, packages and ships cell products collection of Golgi bodies collect, package, and distribute molecules synthesized at one location in the cell and utilized at another location Front - cis , Back – trans and Cisternae – stacked membrane folds Many transport vesicles from the ER travel to the Golgi apparatus for modification of their contents. The Golgi body’s function is manufacturing, warehousing, sorting (Packaging), and shipping materials to outside the cell. The Golgi apparatus is more abundant in secretory cells. The Golgi also manufactures pectin and polysaccharides. It correctly send proteins to their respective address If the Golgi makes a mistake in shipping the proteins to the right address, certain functions in the cell may stop. 

C)- Lysosomes are digestive components The lysosome is a membrane-bounded sac of enzymes that digests macromolecules. Lysosomal enzymes work best at pH = 5 (acidic). The lysosomal enzymes are synthesized by rough ER and then transferred to the Golgi then to lysosomes.

Other Membranous Organelles B)- Mitochondria: They are rod-shaped organelles that convert oxygen and nutrients into ATP (adenosine triphosphate) during aerobic respiration. Mitochondria are the sites of cellular respiration, Generating ATP from the catabolism of sugars, fats, and other fuels in the presence of oxygen. Almost all eukaryotic cells have mitochondria. Mitochondria and chloroplasts are mobile and move around the cell along tracks in the cytoskeleton.