Adnan Custovic, MD, PhD, Hans-Joachim Sonntag, MRes, Iain E

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Presentation transcript:

Evolution pathways of IgE responses to grass and mite allergens throughout childhood Adnan Custovic, MD, PhD, Hans-Joachim Sonntag, MRes, Iain E. Buchan, MD, PhD, Danielle Belgrave, PhD, Angela Simpson, MD, PhD, Mattia C.F. Prosperi, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 6, Pages 1645-1652.e8 (December 2015) DOI: 10.1016/j.jaci.2015.03.041 Copyright © 2015 The Authors Terms and Conditions

Fig 1 Use of nested LCA to infer sensitization patterns and time trajectories. At 3 time points (Age I, Age II, and Age III), sensitizations to 3 allergens (a1, a2, and a3) are measured in the population. The prevalence of these allergens in the study population per each time point is shown below each age landmark outside the boxes. When LCA is applied, at each time point, 1 or more allergen patterns can be found. The square boxes below each age landmark represent the latent space and include sensitization patterns (classes c1-c4) found at each time point. If the same allergen patterns are found at different ages, they are labeled consistently. Subjects can be assigned to a particular class at each time point by looking at their allergen profiles. After this first LCA, the prevalence of classes in the population at each time point can be calculated (not shown for simplicity). A second-stage LCA can be applied to the classes across time points to identify longitudinal patterns of transition/stasis among classes. These are called time trajectories and are shown as lines that connect one class to another in a subsequent age point (t1-t4). Trajectories will have assigned probabilities as well (not shown). Journal of Allergy and Clinical Immunology 2015 136, 1645-1652.e8DOI: (10.1016/j.jaci.2015.03.041) Copyright © 2015 The Authors Terms and Conditions

Fig 2 Latent classes inferred for timothy grass allergens to identify trajectories of cross-sectional sensitization classes over time. Journal of Allergy and Clinical Immunology 2015 136, 1645-1652.e8DOI: (10.1016/j.jaci.2015.03.041) Copyright © 2015 The Authors Terms and Conditions

Fig 3 Latent classes inferred for house dust mite allergens to identify trajectories of cross-sectional sensitization classes over time. Journal of Allergy and Clinical Immunology 2015 136, 1645-1652.e8DOI: (10.1016/j.jaci.2015.03.041) Copyright © 2015 The Authors Terms and Conditions

Fig E1 Nested latent classes inferred for the timothy grass allergens for cross-sectional sensitization profiles. Each class corresponds to a particular distribution of IgE categories in each allergen component (here the probability of being highly sensitized to a specific allergen by each class is depicted). This first-level analysis is carried out at the time points of 5 years (A), 8 years (B), and 11 years (C) of age, and resulting classes are matched across ages based on their IgE distribution patterns. Journal of Allergy and Clinical Immunology 2015 136, 1645-1652.e8DOI: (10.1016/j.jaci.2015.03.041) Copyright © 2015 The Authors Terms and Conditions

Fig E2 Nested latent classes inferred for dust mite allergens for cross-sectional sensitization profiles. Each class corresponds to a particular distribution of IgE categories in each allergen component (here the probability of being highly sensitized to a specific allergen by each class is depicted). This first-level analysis is carried out at the time points of 5 years (A), 8 years (B), and 11 years (C) of age, and resulting classes are matched across ages based on their IgE distribution patterns. Journal of Allergy and Clinical Immunology 2015 136, 1645-1652.e8DOI: (10.1016/j.jaci.2015.03.041) Copyright © 2015 The Authors Terms and Conditions

Fig E3 sIgE levels to timothy grass allergens in different trajectories and their evolution over time. Semiquantitatively discretized IgE levels have been allocated numeric values: 0, negative; 1, low; 2, medium; and 3, high. Bars indicate 95% bootstrap CIs around the mean for each allergen. A, No/low grass sensitization trajectory. B, Late-onset trajectory. C, Early-onset trajectory. Journal of Allergy and Clinical Immunology 2015 136, 1645-1652.e8DOI: (10.1016/j.jaci.2015.03.041) Copyright © 2015 The Authors Terms and Conditions

Fig E4 sIgE levels to house dust mite allergens in different trajectories and their evolution over time. Semiquantitatively discretized IgE levels have been allocated numeric values: 0, negative; 1, low; 2, medium; 3, high. Bars indicate 95% bootstrap CIs around the mean for each allergen. A, Group 1 allergens trajectory. B, Group 2 allergens trajectory. C, Complete mite sensitization trajectory. Journal of Allergy and Clinical Immunology 2015 136, 1645-1652.e8DOI: (10.1016/j.jaci.2015.03.041) Copyright © 2015 The Authors Terms and Conditions