Silvana Balzar, MD, Matthew Strand, PhD, Diane Rhodes, PhD, Sally E

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IgE expression pattern in lung: Relation to systemic IgE and asthma phenotypes Silvana Balzar, MD, Matthew Strand, PhD, Diane Rhodes, PhD, Sally E. Wenzel, MD Journal of Allergy and Clinical Immunology Volume 119, Issue 4, Pages 855-862 (April 2007) DOI: 10.1016/j.jaci.2006.12.642 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Immunostaining for mast cell tryptase and IgE in consecutive tissue sections. Tryptase-positive mast cells in small airway inner and outer wall (A) colocalize with IgE+ cells (B). Original magnification: ×200. Journal of Allergy and Clinical Immunology 2007 119, 855-862DOI: (10.1016/j.jaci.2006.12.642) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Percentages of mast cells expressing IgE in proximal airway (inner wall) and distal airway regions (inner and outer wall and alveolar attachments) of 11 subjects with severe asthma. Lines connect data within subjects. Capital letters identify subjects as atopic (A) or not (NA), whereas numbers indicate the serum IgE (kU/L). Journal of Allergy and Clinical Immunology 2007 119, 855-862DOI: (10.1016/j.jaci.2006.12.642) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 IgE expression and inflammatory cell counts (eosinophils, mast cells, and lymphocytes) in proximal airways of subjects with severe asthma with or without persistent eosinophilia (Eo+ and Eo−, respectively) or mild asthma and in normal subjects. Each column presents median (rectangular bar) and interquartile range (span of error bars). Horizontal lines connect groups that are significantly different (P ≤ .05). Journal of Allergy and Clinical Immunology 2007 119, 855-862DOI: (10.1016/j.jaci.2006.12.642) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Correlation between serum IgE and percentages of mast cells expressing IgE in proximal airways (all subjects included). Vertical dotted line marks normal serum IgE. Atopic subjects (positive skin reaction to aeroallergens) are marked with open circles. Nonatopic subjects (solid circles) that had mast cell-bound IgE in proximal airways are identified as subjects with severe asthma (SA) or normal controls (NC). Journal of Allergy and Clinical Immunology 2007 119, 855-862DOI: (10.1016/j.jaci.2006.12.642) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Regression models evaluating lung function parameters FEV1 and RV as outcomes, and the percentage of mast cells with membrane-bound IgE (%MCIgE+) in proximal airway submucosa as a predictor. Separate estimates were derived for subjects with severe asthma (solid circles and solid line) and mild asthma (open circles and dotted line). The interactions in either model were not significant (P = .12 and P = .70, respectively). Journal of Allergy and Clinical Immunology 2007 119, 855-862DOI: (10.1016/j.jaci.2006.12.642) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions