Dynamics of an Aging Genome

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Presentation transcript:

Dynamics of an Aging Genome Amalio Telenti, Brad A. Perkins, J. Craig Venter Cell Metabolism Volume 23, Issue 6, Pages 949-950 (June 2016) DOI: 10.1016/j.cmet.2016.06.002 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The Aging Genome Interindividual differences in the burden of common variants (green) associated with metabolic, cardiovascular, and neurodegenerative diseases, as well as the less-documented contributions of rare variants (red), add to the germline (inherited) genome contribution to aging. During life, there are dynamic changes of the genome at cellular and tissue level—through somatic mutation (increase n number of red loci) and telomere shortening (yellow) and loss of integrity and number of the chromosomes. Cell Metabolism 2016 23, 949-950DOI: (10.1016/j.cmet.2016.06.002) Copyright © 2016 Elsevier Inc. Terms and Conditions