Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets.

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Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. MISTRG mice infected with YU-2 were sacrificed 5 or 12–20 wk p.i., and splenocytes were analyzed for differentiation and PD-1 expression. (A) Definition of T cell differentiation subsets. (B) Frequency of TN (blue), TEMRA (orange), TCM (pink), and TEM (gray) in CD4+ and CD8+ T cell subsets in the spleen during acute infection (upper panel) (MISTRG HIV−, n = 7; HIV+, n = 6) and chronic infection (lower panel) (MISTRG HIV−, n = 6, HIV+, n = 6). Median fluorescent intensity of PD-1 in uninfected and infected MISTRG mice on CD4+ (C) and CD8+ (D) T cell subsets in acute (upper panels) and chronic (lower panels) HIV infection. Data are mean ± SEM. *p < 0.05, **p < 0.01, two-tailed Mann–Whitney U test. Sandra Ivic et al. ImmunoHorizons 2017;1:162-175 Copyright © 2017 The Authors