Introducing a New Dimension to Molecular Disease Classifications

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Introducing a New Dimension to Molecular Disease Classifications Noémie Jourde-Chiche, Laurent Chiche, Damien Chaussabel Trends in Molecular Medicine Volume 22, Issue 6, Pages 451-453 (June 2016) DOI: 10.1016/j.molmed.2016.04.005 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 The Pharmacological Wheel of Fortune. (A) A single clinical diagnosis (e.g., systemic lupus erythematous; SLE) can encompass groups of patients whose disease is driven by distinct molecular mechanisms. This heterogeneity is underpinned by complex gene variant interactions. In this simplified example, there are six equally proportioned groups of patients. Therefore, the predicted response rate to an efficacious drug is at best 17% (one in six). (B) Correlating serial high-resolution molecular profiles with the disease course classify and pairing patients with an appropriate therapeutic intervention strategy. Such molecular phenotyping approaches could provide a new paradigm for establishing ‘molecular diagnosis–treatment continuums’. Trends in Molecular Medicine 2016 22, 451-453DOI: (10.1016/j.molmed.2016.04.005) Copyright © 2016 Elsevier Ltd Terms and Conditions