Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy Kyung-Jong Yoo, MD, Ren-Ke Li, MD, PhD, Richard D. Weisel,

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Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy Kyung-Jong Yoo, MD, Ren-Ke Li, MD, PhD, Richard D. Weisel, MD, Donald A.G. Mickle, MD, Guangming Li, MD, Terrence M. Yau, MD, MSc The Annals of Thoracic Surgery Volume 70, Issue 3, Pages 859-865 (September 2000) DOI: 10.1016/S0003-4975(00)01630-1

Fig 1 Photomicrograph of cultured smooth muscle cells (A) (100×) that stained positively for α-smooth muscle actin (B) (200×). The Annals of Thoracic Surgery 2000 70, 859-865DOI: (10.1016/S0003-4975(00)01630-1)

Fig 2 Photomicrograph of control (A; 40×) and cell transplanted hearts (B; 100×) of 21-week-old cardiomyopathic hamsters (hematoxylin and eosin). The cardiomyopathic host myocardium shows severe focal necrosis (N) and fibrosis (F). The transplanted smooth muscle cells formed musclelike tissue (T), in which multiple small-caliber blood vessels were noted (arrow). The Annals of Thoracic Surgery 2000 70, 859-865DOI: (10.1016/S0003-4975(00)01630-1)

Fig 3 Photomicrograph of transplanted smooth muscle cells in the transplanted hearts. Sections from hearts transplanted with 5-bromo-2′-deoxyuridine-prelabeled cells were stained with hematoxylin and immunohistochemically for 5-bromo-2′-deoxyuridine (100×). Musclelike tissue, which stained positively for 5-bromo-2′-deoxyuridine (arrows), was found in the smooth muscle cell-transplanted hearts but not in the control or sham-operated hearts. The Annals of Thoracic Surgery 2000 70, 859-865DOI: (10.1016/S0003-4975(00)01630-1)

Fig 4 Photomicrograph of the musclelike tissue formed by the transplanted smooth muscle cells, stained immunohistochemically for α-smooth muscle actin (arrows) (100×). The Annals of Thoracic Surgery 2000 70, 859-865DOI: (10.1016/S0003-4975(00)01630-1)

Fig 5 Peak systolic (A) and developed left ventricular pressures (B) in the transplanted, control, and sham-operated hearts over a range of intraventricular balloon volumes (mean ± standard deviation). Peak systolic and developed pressures in the transplantation group were significantly higher than in the control and sham-operated groups (p < 0.001). There were no significant differences between control and sham-operated hearts. The Annals of Thoracic Surgery 2000 70, 859-865DOI: (10.1016/S0003-4975(00)01630-1)

Fig 6 Maximum left ventricular +dp/dt (A) and −dp/dt (B) in the transplanted, control, and sham-operated hearts over a range of intraventricular balloon volumes (mean ± standard deviation). Maximum +dp/dt was significantly higher, and maximum −dp/dt was significantly lower, in the transplantation group than in the control and sham operated groups (p < 0.001). There were no significant differences between control and sham-operated hearts. The Annals of Thoracic Surgery 2000 70, 859-865DOI: (10.1016/S0003-4975(00)01630-1)

Fig 7 Active (A) and passive (B) left ventricular diastolic pressures in the transplanted, control, and sham-operated hearts over a range of intraventricular balloon volumes (mean ± standard deviation). Diastolic pressures in the transplanted hearts were significantly higher, at any intraventricular balloon volume, than in the control and sham-operated groups (p < 0.001). There were no significant differences between control and sham-operated hearts. The Annals of Thoracic Surgery 2000 70, 859-865DOI: (10.1016/S0003-4975(00)01630-1)