Systemic inflammation and higher perception of dyspnea mimicking asthma in obese subjects Carlos Carpio, MD, Carlos Villasante, MD, Raúl Galera, MD,

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Presentation transcript:

Systemic inflammation and higher perception of dyspnea mimicking asthma in obese subjects Carlos Carpio, MD, Carlos Villasante, MD, Raúl Galera, MD, David Romero, MD, Ana de Cos, MD, Angel Hernanz, MD, Francisco García-Río, MD Journal of Allergy and Clinical Immunology Volume 137, Issue 3, Pages 718-726.e4 (March 2016) DOI: 10.1016/j.jaci.2015.11.010 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Dyspnea during exercise in the 3 study groups. Values are means ± SEMs. The Borg/V′O2 slopes are significantly greater (P < .01) in subjects with asthma or misdiagnosed asthma than in nonasthmatic subjects. Journal of Allergy and Clinical Immunology 2016 137, 718-726.e4DOI: (10.1016/j.jaci.2015.11.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Correlation between the perception of dyspnea during the bronchial challenge and serum levels of adiponectin (A) and IL-1β (B). Journal of Allergy and Clinical Immunology 2016 137, 718-726.e4DOI: (10.1016/j.jaci.2015.11.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Correlation between exertional dyspnea (evaluated by the slope of Borg ratings over V′O2 [Borg/V′O2 slope]) and residual volume (A), peak respiratory frequency (B), peak ventilatory equivalent of CO2 (ΔVE/ΔV′CO2; C), and serum levels of inflammatory biomarkers (D-F). Journal of Allergy and Clinical Immunology 2016 137, 718-726.e4DOI: (10.1016/j.jaci.2015.11.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Borg/work rate slopes during exercise in the 3 study groups. Values are means ± SEMs. The dyspnea threshold (x-intercept) was significantly greater (P < .001) in subjects with asthma or misdiagnosed asthma than in nonasthmatic subjects. Journal of Allergy and Clinical Immunology 2016 137, 718-726.e4DOI: (10.1016/j.jaci.2015.11.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Correlation between the perception of dyspnea during the bronchial challenge and age. Journal of Allergy and Clinical Immunology 2016 137, 718-726.e4DOI: (10.1016/j.jaci.2015.11.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Correlations of IL-1β and leptin levels with the dyspnea threshold (A and C) and maximal dyspnea load (B and D, respectively). Journal of Allergy and Clinical Immunology 2016 137, 718-726.e4DOI: (10.1016/j.jaci.2015.11.010) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions