CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy Kelli R. Ryan, PhD, Catherine.

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Presentation transcript:

CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy Kelli R. Ryan, PhD, Catherine A. Lawson, MRCP, Alice R. Lorenzi, MRCP, Peter D. Arkwright, PhD, John D. Isaacs, PhD, Desa Lilic, PhD Journal of Allergy and Clinical Immunology Volume 116, Issue 5, Pages 1158-1159 (November 2005) DOI: 10.1016/j.jaci.2005.08.036 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Patients with APECED have fewer T lymphocytes bearing regulatory phenotype. Peripheral blood CD4+ cells from AIRE−/− patients and age-matched controls were assessed by flow cytometry for cell surface markers CD4/CD25 (A) or CD4/CD25/GITR (B). Lines represent medians; in (A), the right Y axis applies to the right panel. FOXP3 transcripts for total CD4+ cells were quantified relative to GAPDH by RT-PCR (C). Pts, Patients; ctrl, controls. Journal of Allergy and Clinical Immunology 2005 116, 1158-1159DOI: (10.1016/j.jaci.2005.08.036) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions