BayesAS and GBLUP models

Slides:



Advertisements
Similar presentations
15 The Genetic Basis of Complex Inheritance
Advertisements

Problem #1 X H = Chromosome with allele for Normal Blood Clotting X h = Chromosome with allele for Hemophilia Y = Chromosome without an allele for blood.
Phenotypes for training and validation of genome wide selection methods K G DoddsAgResearch, Invermay B AuvrayAgResearch, Invermay P R AmerAbacusBio, Dunedin.
Added value of whole-genome sequence data to genomic predictions in dairy cattle Rianne van Binsbergen 1,2, Mario Calus 1, Chris Schrooten 3, Fred van.
John Genho NBCEC Brown Bagger Series
1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.
Traits & Environment Pp What are traits? Hair color Eye color HeightWeight Male vs. Female.
Develop 50K prediction equation suitable for estimation of Molecular Breeding Values (MBV) for Limousin and LimFlex (hybrid) animals Use 50K imputed genotypes.
Molecular ecology, quantitative genetic and genomics Dave Coltman + Melissa Gunn, Andrew Leviston, Katie Hartnup & Jon Slate.
Training, Validation, and Target Populations Training, Validation, and Target Populations Mark Thallman, Kristina Weber, Larry Kuehn, Warren Snelling,
Impacts of inclusion of foreign data in genomic evaluation of dairy cattle K. M. Olson 1, P. M. VanRaden 2, D. J. Null 2, and M. E. Tooker 2 1 National.
Van Eenennaam 11/17/2010 Animal Genomics and Biotechnology Education Alison Van Eenennaam, Ph.D. Cooperative Extension Specialist Animal Biotechnology.
Selection for Lifetime Production
11.3 Other Patterns of Inheritance
Multiple Alleles Practice Problems.
J. B. Cole * and P. M. VanRaden Animal Improvement Programs Laboratory Agricultural Research Service, USDA Beltsville, MD
Gilles Charmet1*, Van Giang Tran1, Delphine Ly1 ,Jerome Auzanneau2
April 2010 (1) Prediction of Breed Composition & Multibreed Genomic Evaluations K. M. Olson and P. M. VanRaden.
Council on Dairy Cattle Breeding April 27, 2010 Interpretation of genomic breeding values from a unified, one-step national evaluation Research project.
REVIEW GENETICS- the study of heredity. Inheritance Traits are specific characteristics inherited from parents Genes are the factors that determine traits.
CHAPTER 12: GENETICS.
2007 Paul VanRaden Animal Improvement Programs Lab, Beltsville, MD Iterative combination of national phenotype, genotype, pedigree,
Introduction to Genetics. Your envelope has 4 fish Red fish- female traits Blue fish- male traits Work with a partner to determine what the offspring.
Multibreed Genomic Evaluation Using Purebred Dairy Cattle K. M. Olson* 1 and P. M. VanRaden 2 1 Department of Dairy Science Virginia Polytechnic and State.
VISG – LARGE DATASETS Literature Review Introduction – Genome Wide Selection Aka Genomic Selection Set of Markers 10,000’s - enough to capture most genetic.
Whole genome selection and the 2000 bull project at USMARC Larry Kuehn Research Geneticist.
1/12/15 Objective: What factors influence typical inheritance Do Now: Take out your HW genetics problems.
Multibreed Genomic Evaluations in Purebred Dairy Cattle K. M. Olson 1 and P. M. VanRaden 2 1 National Association of Animal Breeders 2 AIPL, ARS, USDA.
Genes and Variation Genotypes and phenotypes in evolution Natural selection acts on phenotypes and does not directly on genes. Natural selection.
What gains can we expect from Genetics?
EAAP Meeting, Stavanger Estimation of genomic breeding values for traits with high and low heritability in Brown Swiss bulls M. Kramer 1, F. Biscarini.
May 4, What is an allele?. Genotype: genetics of trait (what alleles?) Homozygous: two copies of the same allele –Homozygous dominant (BB) –Homozygous.
Partitioning of variance – Genetic models
A Multi-stage Approach to Detect Gene-gene Interactions Associated with Multiple Correlated Phenotypes Zhou Xiangdong,Keith Chan, Danhong Zhu Department.
Introduction to Genetics and Heredity
TOPIC: Genetics AIM: How are human traits inherited?
Complex Genomic Trait Predictions to Accelerate Plant Breeding Programs Kelci Miclaus1, Luciano da Costa e Silva1 , and Lauro Jose Moreira Guimaraes2.
Y. Masuda1, I. Misztal1, P. M. VanRaden2, and T. J. Lawlor3
Ch. 9: Complete Inheritance
Incomplete Dominance:
Genetics Gregor Mendel *The father of genetics.
Genetics Practice Problems
15 The Genetic Basis of Complex Inheritance
A few Simple Applications of Index Selection Theory
Initial activity: What do you notice?
Mapping Quantitative Trait Loci
Lab: Pedigree Analysis
The effect of using sequence data instead of a lower density SNP chip on a GWAS EAAP 2017; Tallinn, Estonia Sanne van den Berg, Roel Veerkamp, Fred van.
S. Naderi1, R. R. Mota1, S. Vanderick1, N. Gengler1
CHAPTER 12: GENETICS.
Sci9ence of Heredity Lessons 1 & 2
Genotypes & Phenotypes
Methods to compute reliabilities for genomic predictions of feed intake Paul VanRaden, Jana Hutchison, Bingjie Li, Erin Connor, and John Cole USDA, Agricultural.
Washington State University
Lecture #24 **change PPT Guide # to 27
The Monohybrid Cross ….
Determining Sex.
Simple Genetics Thursday, October 19, 2011.
Male genotype _______________________
gene mapping & pedigrees
Predictions of Breed Composition Using Holsteins, Jersey, and Brown Swiss Genotypes K. M. Olson and P. M. VanRaden.
Genetics Project - Design a Species
Increased reliability of genetic evaluations for dairy cattle in the United States from use of genomic information Abstr.
3.3 Patterns of Inheritance
Test Crosses.
1. What animal 2. Male or Female ? 4. Male or Female? Why? Why?
Sex linked inheritance
Development of Genomic GMACE
The Basic Genetic Model
Day 61 -Genetics Vocabulary Test -Finish Reviewing Punnett Squares
Presentation transcript:

BayesAS and GBLUP models for genomic selection in Mink T. Villumsen1, G. Su 1, Z. Cai 1, B. Guldbrandtsen 1, T. Asp 1, G. Sahana 1, M.S. Lund 1 1 Department of Molecular Biology and Genetics, Aarhus University (DK). Conclusions: Multiple trait models generally didn’t perform better than single trait models for our mink data BayesAS models allowing heterogeneous (co)variance over the genome were superior to GBLUP models Questions: Does a multiple trait model perform better than a than single trait model? Is a model that accounts for heterogeneous (co)variance over the genome (BayesAS)superior to a GBLUP model for our mink data? Results: Data: Foulum brown line 28,336 SNP-markers in 391 scaffolds 2013 Accuracy of prediction in the 5-fold cross validation for 2014 200 Males Geno- & Phenotypes 800 Females Geno- & Phenotypes   Trait No of Animals ST-GBLUP MT-GBLUP ST-BayesAS MT-BayesAS Live grad. Weight1 752 0.490 0.5001 0.516 0.5231 Quality 0.685 0.694 0.695 0.706 Density 0.393 0.462 0.450 0.459 Silky 0.820 0.818 0.844 0.843 Dried skins P_length 639 0.480 0.489 0.618 0.624 P_quality 665 0.227 0.234 0.270 0.258 P_density 0.299 0.302 0.357 0.362 P_silky 0.138 0.135 0.197 0.194 6000 Progeny Live- and Peltgrading 2014 200 Males Geno- & Phenotypes 400 Females Geno- & Phenotypes 6000 Progeny Live- and Peltgrading 840 Genotyped Models: MT-GBLUP: MT-BayesAS: Hierarchial model, handle correlation between SNP effects: Not a clear tendency for MT-models to be better than ST-models BayesAS superior to GBLUP models BayesAS GEBV increased more for pelt traits than live grading traits All traits analyzed with weight in MT-analyses. Results for weight: analyzed with P_length AU AARHUS UNIVERSITY DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS