What exactly is synthetic biology?

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Presentation transcript:

What exactly is synthetic biology? Michael Gross  Current Biology  Volume 21, Issue 16, Pages R611-R614 (August 2011) DOI: 10.1016/j.cub.2011.08.002 Copyright © 2011 Terms and Conditions

Artificial everything: Steven Benner's group made the first artificial gene encoding a protein and has since then moved on to create a whole range of non-natural molecular biology ingredients. (Photo: courtesy of Steven Benner.) Current Biology 2011 21, R611-R614DOI: (10.1016/j.cub.2011.08.002) Copyright © 2011 Terms and Conditions

Close collaboration: Self-assembling fibrils and sheets of RNA can help to keep two proteins in close proximity to each other within the bacterial cell and can thereby enhance their productivity. In the proof-of-principle example published in Science magazine in July, the RNA scaffolds speed up the production of hydrogen which requires the joint activity of the proteins ferredoxin and hydrogenase. (Photo: Reprinted with permission from AAAS.) Current Biology 2011 21, R611-R614DOI: (10.1016/j.cub.2011.08.002) Copyright © 2011 Terms and Conditions

Synthesizing life: One of the motivations behind attempts to create living entities synthetically is the desire to understand how life on Earth originated. This field was launched by the pioneering experiments of Stanley Miller (1930–2007), who showed that simulated primeval Earth conditions can produce amino acids from simple and abundant molecules. (Photo: SCIENCE PHOTO LIBRARY.) Current Biology 2011 21, R611-R614DOI: (10.1016/j.cub.2011.08.002) Copyright © 2011 Terms and Conditions