Hierarchical structure in the yeast transcription regulatory network.

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Hierarchical structure in the yeast transcription regulatory network. Hierarchical structure in the yeast transcription regulatory network. (A) Yeast regulatory network containing 13 385 regulatory interactions among 4503 genes, which includes 158 transcription factors (TFs) and 4369 target genes (TGs). (B) Vertex sort of TFs in the regulatory network reveals a hierarchical organizational structure (left panel). Middle panel depicts a schematic showing the inherent hierarchical structure with the number of regulatory interactions among TFs within and across layers, and those between TFs and TGs. The central skeleton of the hierarchy resembles a feed‐forward structure spanning three basic non‐overlapping layers, shown in red, green and blue (right panel). (C) Detailed hierarchical organization of yeast TFs. TFs within each block (polygon) can occupy any of the levels spanned by the block. Nine TFs in the right‐most column are not a part of the hierarchy, as they are not connected to any other TF in the network. The hierarchal organization of TFs in the network naturally clusters into three basic non‐overlapping layers: the top (red), core (green), and bottom (blue). Thirty‐two regulatory hubs are highlighted in bold and marked with a star (*), and nine essential TFs are marked with an arrow. Raja Jothi et al. Mol Syst Biol 2009;5:294 © as stated in the article, figure or figure legend