Figure 2 Comparison of the developing mouse kidney

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Figure 2 Comparison of the developing mouse kidney and a kidney organoid generated from human pluripotent stem cells Figure 2 | Comparison of the developing mouse kidney and a kidney organoid generated from human pluripotent stem cells. The development of human pluripotent cell (hPSC)-derived kidney organoids after 11 days of culture in aggregates can be compared to that of the mouse embryonic kidney at embryonic day (E) 15.5 using immunofluorescence on wholemount preparations (a,c) or paraffin sections (e,g,i), or immunohistochemistry (b,d) and/or RNA in situ hybridisation (b,f,h,j) on paraffin sections. a,b | Early capillary loop stage development of a nephron showing the location of WT1+ (pink) NPHS1+ (green) and WT1+ (brown) pre-podocytes and the expression of Wnt4 (b, blue) in the medial nephron. c,d | Capillary loop stage nephrons showing NPHS1+ (green) and WT1+ (brown) podocytes with invading endothelium (PECAM+, pink, c). e,f | Maturing proximal tubules illustrating the presence of the brush border, which is LRP2+ (green), CUBILIN+ (pink) in e and Lrp2+ (blue) in f. g,h | PECAM+ (white, g)/Pecam+ (blue, h) vascular endothelial networks. Glomeruli in g are marked by NPHS1 protein (pink). i,j | MEIS1+ (pink)/Meis1+ (blue) interstitial cells between forming nephrons. Panels a,c and i reproduced from Takasato et al.11, Nature Publishing Group. Panels a,c and i reproduced from Takasato et al.11, Nature Publishing Group. Little, M. H. et al. (2016) Understanding kidney morphogenesis to guide renal tissue regeneration Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.126