Improving the Accuracy of Mesothelioma Diagnosis in China

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Improving the Accuracy of Mesothelioma Diagnosis in China Zhenying Guo, MD, Michele Carbone, MD, PhD, Xing Zhang, PhD, Dan Su, MD, PhD, Wenyong Sun, MD, Jianlin Lou, PhD, Zhibin Gao, MD, Dichu Shao, MD, Junqiang Chen, MD, Gu Zhang, BS, Jinlin Hu, BS, Kaiyan Chen, MD, Fang Wang, MD, Harvey I. Pass, MD, Herbert Yu, MD, PhD, Andrea Napolitano, MD, PhD, Haining Yang, MD, PhD, Weimin Mao, MD Journal of Thoracic Oncology Volume 12, Issue 4, Pages 714-723 (April 2017) DOI: 10.1016/j.jtho.2016.12.006 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Immunohistochemistry results for epithelial malignant mesothelioma (MM) and lung adenocarcinoma. (Left column) Epithelial MM positive for calretinin, Wilms tumor 1 (WT1), D2-40, and CAM5.2 and negative for CD15 and thyroid transcription factor-1 (TTF-1). (Right column) Lung adenocarcinoma positive for CAM5.2, CD15, and TTF-1 and negative for calretinin, WT1, and D2-40. Original magnification of main portion of all slides, ×100; original magnification of insets at right lower corner of each slide, ×400. HE, hematoxylin and eosin. Journal of Thoracic Oncology 2017 12, 714-723DOI: (10.1016/j.jtho.2016.12.006) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Immunohistochemistry results for biphasic malignant mesothelioma (MM) and carcinosarcoma of the kidney, with both sets of slides showing a clear cell component. (Left column) Biphasic MM positive for calretinin and D2-40 and negative for Wilms tumor 1 (WT1), CAM5.2, CD15, and thyroid transcription factor-1 (TTF-1). (Right column) Carcinosarcoma of the kidney positive for CD15 and paired box 8 (PAX-8); negative for calretinin, WT1, and D2-40; and negative/weakly positive for CAM5.2. Original magnification, ×400. HE, hematoxylin and eosin. Journal of Thoracic Oncology 2017 12, 714-723DOI: (10.1016/j.jtho.2016.12.006) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Expression of BRCA1 associated protein 1 (BAP1) and INO80 in malignant mesothelioma (MM). (Top row) MM, epithelial type, showing negative nuclear staining for BAP1 and for Ino80. (Middle row) Biphasic MM showing homogeneous BAP1 and Ino80 nuclear staining. (Bottom row) Sarcomatoid MM showing focal nuclear staining for BAP1 and for Ino80. Original magnification, ×400. Arrows point at tumor cells showing nuclear staining. HE, hematoxylin and eosin. Journal of Thoracic Oncology 2017 12, 714-723DOI: (10.1016/j.jtho.2016.12.006) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Supplementary Figure 1 Journal of Thoracic Oncology 2017 12, 714-723DOI: (10.1016/j.jtho.2016.12.006) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Supplementary Figure 2 Journal of Thoracic Oncology 2017 12, 714-723DOI: (10.1016/j.jtho.2016.12.006) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions