Low-level ozone has both respiratory and systemic effects in African American adolescents with asthma despite asthma controller therapy Michelle L. Hernandez,

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Presentation transcript:

Low-level ozone has both respiratory and systemic effects in African American adolescents with asthma despite asthma controller therapy Michelle L. Hernandez, MD, Radhika Dhingra, PhD, Allison J. Burbank, MD, Krista Todorich, MD, Ceila E. Loughlin, MD, Marcia Frye, MD, Kelly Duncan, PhD, Carole Robinette, MS, Katherine Mills, BA, Robert B. Devlin, PhD, David B. Peden, MD, David Diaz-Sanchez, PhD Journal of Allergy and Clinical Immunology Volume 142, Issue 6, Pages 1974-1977.e3 (December 2018) DOI: 10.1016/j.jaci.2018.08.003 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Changes in lung function with ambient ozone concentrations. A, Change in percent predicted forced vital capacity (FVC). B, Change in percent predicted FEV1 under a single-pollutant model for ozone. Effect estimates and 95% CIs are shown and correspond to changes per interquartile range (IQR) of ozone for the day of examination (lag 0) for each of the 4 preceding days (lags 1-4) and for the 5-day moving average (5dMA). All models were adjusted for temperature and humidity. Journal of Allergy and Clinical Immunology 2018 142, 1974-1977.e3DOI: (10.1016/j.jaci.2018.08.003) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Ozone's effects on blood lipid levels. Changes in total cholesterol (A) and low-density lipoprotein (LDL; B) levels (in milligrams per deciliter) are shown. Effect estimates and 95% CIs are shown and correspond to changes per interquartile range (IQR) of ozone for the day of examination (lag 0) for each of the 4 preceding days (lags 1-4) and for the 5-day moving average (5dMA). A single-pollutant model for ozone was used and adjusted for temperature and humidity. Journal of Allergy and Clinical Immunology 2018 142, 1974-1977.e3DOI: (10.1016/j.jaci.2018.08.003) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Ambient ozone levels throughout the study period. Daily ozone (parts per billion) concentrations, 24-hour average (red line) and 8-hour maximum (blue line), from August 2013 to November 2014 are shown. Values were calculated from a central monitor. The horizontal line represents the current NAAQS for ground-level ozone of 70 ppb. Journal of Allergy and Clinical Immunology 2018 142, 1974-1977.e3DOI: (10.1016/j.jaci.2018.08.003) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions