Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group,

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Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial Jean T Coulibaly, PhD, Gordana Panic, PhD, Kigbafori D Silué, PhD, Jana Kovač, MSc, Jan Hattendorf, PhD, Prof Jennifer Keiser, PhD The Lancet Global Health Volume 5, Issue 7, Pages e688-e698 (July 2017) DOI: 10.1016/S2214-109X(17)30187-0 Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Trial profile PSAC=preschool-aged children. SAC=school-aged children. S mansoni=Schistosomiasis mansoni. The Lancet Global Health 2017 5, e688-e698DOI: (10.1016/S2214-109X(17)30187-0) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Cure rates in PSAC (blue lines) and SAC (red lines) Circles show observed cure rates with 95% CIs (vertical lines). Numbers and colour code in the circles show geometric mean infection intensities at baseline (BL). Dashed lines represent the estimated dose–response curve and corresponding 95% confidence bands predicted by the Emax models. Epg=eggs per gram of stool. PSAC=preschool-aged children. SAC=school-aged children. The Lancet Global Health 2017 5, e688-e698DOI: (10.1016/S2214-109X(17)30187-0) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Egg reduction rates in PSAC (blue lines) and SAC (red lines) Diamonds show observed cure rates with 95% CIs (vertical lines). Dashed lines represent the estimated dose response curve and corresponding 95% confidence bands predicted by the Emax model. PSAC=preschool-aged children. SAC=school-aged children. The Lancet Global Health 2017 5, e688-e698DOI: (10.1016/S2214-109X(17)30187-0) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions