Volume 381, Issue 9884, Pages (June 2013)

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Presentation transcript:

Volume 381, Issue 9884, Pages 2176-2183 (June 2013) Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study Prof Debbie A Lawlor, PhD, Andrew K Wills, PhD, Abigail Fraser, PhD, Adrian Sayers, MSc, Prof William D Fraser, MD, Prof Jonathan H Tobias, PhD The Lancet Volume 381, Issue 9884, Pages 2176-2183 (June 2013) DOI: 10.1016/S0140-6736(12)62203-X Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile ALSPAC= Avon Longitudinal Study of Parents and Children. 25(OH)D=25-hydroxyvitamin D. DXA=dual-energy x-ray absorptiometry. The Lancet 2013 381, 2176-2183DOI: (10.1016/S0140-6736(12)62203-X) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 2 Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by multivariate multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation. The Lancet 2013 381, 2176-2183DOI: (10.1016/S0140-6736(12)62203-X) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 3 Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester and sex of offspring (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D. Values missing for covariables were calculated by multivariate multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation. The Lancet 2013 381, 2176-2183DOI: (10.1016/S0140-6736(12)62203-X) Copyright © 2013 Elsevier Ltd Terms and Conditions