Cell Division: Centrosomes Have Separation Anxiety Stephen R. Norris, Ryoma Ohi  Current Biology  Volume 27, Issue 12, Pages R601-R603 (June 2017) DOI: 10.1016/j.cub.2017.04.050 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Centrosome tethering by Kif25. (A) An established pathway for centrosome tethering. Centrosome separation is activated by epidermal growth factor (EGF) [9], which activates signaling cascades culminating in the phosphorylation and dissociation of the centrosomal linker proteins C-Nap1 and Rootletin. Figure adapted from Bahe et al. [4]. (B) A second, microtubule-dependent centrosome tethering pathway relies on inward forces generated by Kif25, as described by Decarreau et al. [10]. The microtubule minus-end activity of Kif25 appears to balance the outward forces generated by the plus-end directed motor kinesin-5/Eg5. Current Biology 2017 27, R601-R603DOI: (10.1016/j.cub.2017.04.050) Copyright © 2017 Elsevier Ltd Terms and Conditions