Taking Psychiatry Research Online

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Taking Psychiatry Research Online Claire M. Gillan, Nathaniel D. Daw Neuron Volume 91, Issue 1, Pages 19-23 (July 2016) DOI: 10.1016/j.neuron.2016.06.002 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Big Data in Psychiatry Can Be Realized with Internet Testing Figure reproduced from Gillan et al. (2016). Factor analysis of items from nine popular psychiatric self-report questionnaires in 1,413 individuals reveals a three-factor solution, comprising “Anxious-Depression” (F1), “Compulsive Behavior and Intrusive Thought” (F2), and “Social Withdrawal” (f3). Item descriptors from F2 (left) highlight how symptoms of compulsive behavior and intrusive thought can be found across questionnaires that purport to quantify discrete clinical phenomena. In an independent analysis, F2 was the only trans-diagnostic predictor of goal-directed deficits, which have been previously linked to the integrity of caudate function. The magnitude of this effect exceeded that of any of the nine original questionnaires that reflect more traditional psychiatric constructs. Error bars denote SEM. Neuron 2016 91, 19-23DOI: (10.1016/j.neuron.2016.06.002) Copyright © 2016 Elsevier Inc. Terms and Conditions