Figure 1 Histopathologic features of a chronic active and a chronic plaque in the MS brain Histopathologic features of a chronic active and a chronic plaque.

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Figure 1 Histopathologic features of a chronic active and a chronic plaque in the MS brain Histopathologic features of a chronic active and a chronic plaque in the MS brain Representative hematoxylin & eosin (H&E) staining (A–C) and immunohistochemistry (D–L) of active MS (A, D, G, J), chronic MS (B, E, H K), and healthy control (C, F, I, L) brain samples. Perivascular (PV) inflammation (A and B), demyelination, as indicated by the loss of MBP staining (black arrows) (D and E), presence of inflammatory cells, CD3+ T lymphocytes (red arrowheads) were prominent within active MS lesions (G) and present to a lesser extent in chronic MS lesions (H). Numerous macrophages/microglia (black arrowheads) were observed in and around PV cuffs in active MS (J) and were also observed chronic MS lesions, although to a lesser extent (K). Healthy controls, without neurologic disease, showed little or no CD3+ immunoreactivity (I) and positive CD68+ immunostaining in the parenchyma resembling resident microglia (black arrowheads) (L). Normal tonsils were used as a positive control and show CD3+ (M) and CD68+ (N) immunostaining. CAP = chronic active plaque, CP = chronic plaque. Scale bars = 50 μm. Monica A. Moreno et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e466 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.