Volume 139, Issue 4, Pages e1 (October 2010)

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Volume 139, Issue 4, Pages 1106-1114.e1 (October 2010) Endoscopic Tri-Modal Imaging Is More Effective Than Standard Endoscopy in Identifying Early-Stage Neoplasia in Barrett's Esophagus Wouter L. Curvers, Lorenza Alvarez Herrero, Michael B. Wallace, Louis–Michel Wong Kee Song, Krish Ragunath, Herbert C. Wolfsen, Ganapathy A. Prasad, Kenneth K. Wang, Venkataraman Subramanian, Bas L.A.M. Weusten, Fiebo J. Ten Kate, Jacques J.G.H.M. Bergman Gastroenterology Volume 139, Issue 4, Pages 1106-1114.e1 (October 2010) DOI: 10.1053/j.gastro.2010.06.045 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 (A–C) A lesion containing HGD/Ca is depicted at the 11 o'clock position. (A) A more prominent lesion located at the 5 o'clock position is shown. Both lesions were detected with HRE and AFI. NBI showed irregular mucosal and vascular patterns suspicious for dysplasia. (D and E) Two lesions with HGD/Ca located at the 2 and the 5 o'clock positions are shown. These lesions were missed during HRE but were subsequently detected with AFI (E). NBI (F) showed irregular mucosal and vascular patterns and abnormal blood vessels suspicious for dysplasia. AFI, autofluorescence imaging; Ca, Carcinoma; HGD, high-grade dysplasia; HRE, high-resolution endoscopy; NBI, narrow band imaging. Gastroenterology 2010 139, 1106-1114.e1DOI: (10.1053/j.gastro.2010.06.045) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Images G and H show an AFI false-positive lesion. Detailed inspection with NBI (Image I) showed regular mucosal and regular vascular patterns not suspicious for dysplasia. Histopathology revealed non-dysplastic BE. AFI: autofluoresence imaging; NBI: narrow band imaging; BE: Barrett's eosphagus. Gastroenterology 2010 139, 1106-1114.e1DOI: (10.1053/j.gastro.2010.06.045) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 Flow chart of eligible patients. ETMI, endoscopic tri-modal imaging; pt, patient; SVE, standard video endoscopy. Gastroenterology 2010 139, 1106-1114.e1DOI: (10.1053/j.gastro.2010.06.045) Copyright © 2010 AGA Institute Terms and Conditions