Jacob N. Schroder, MD, Mani A. Daneshmand, MD, Nestor R

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Heparin-Induced Thrombocytopenia in Left Ventricular Assist Device Bridge-to- Transplant Patients Jacob N. Schroder, MD, Mani A. Daneshmand, MD, Nestor R. Villamizar, MD, Rebecca P. Petersen, MD, Laura J. Blue, NP, Ian J. Welsby, MD, Andrew J. Lodge, MD, Thomas L. Ortel, MD, PhD, Joseph G. Rogers, MD, Carmelo A. Milano, MD The Annals of Thoracic Surgery Volume 84, Issue 3, Pages 841-846 (September 2007) DOI: 10.1016/j.athoracsur.2007.03.049 Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Antiheparin/platelet factor-4 (HPF4) levels from the time of diagnosis to transplantation. The absolute change in HPF4 level from the time of diagnosis to transplantation is represented for each of the 17 ventricular assist device patients who were positive for heparin-induced thrombocytopenia. The average decline in HPF4 level is represented by the heavy line. The dashed line represents 0.4 optical density (OD) units, the upper limit of normal for the HPF4 enzyme-linked immunosorbent assay at our institution. The Annals of Thoracic Surgery 2007 84, 841-846DOI: (10.1016/j.athoracsur.2007.03.049) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Percentage change in platelet counts after transplantation. Comparison of the percentage change in mean daily platelet counts from 1 day before transplantation (preTx) to 1 month after transplant (PostTx). Heparin-induced thrombocytopenia–positive ventricular assist device patients (squares) had significantly greater decreases in platelet counts postoperative day (POD) 1 through 4 compared with control (triangles). The Annals of Thoracic Surgery 2007 84, 841-846DOI: (10.1016/j.athoracsur.2007.03.049) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Kaplan-Meier analysis of survival after transplantation. Patients positive for heparin-induced thrombocytopenia (HIT+ [solid line]) versus control (dashed line). The Annals of Thoracic Surgery 2007 84, 841-846DOI: (10.1016/j.athoracsur.2007.03.049) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Kaplan-Meier analysis of thromboembolic-free survival after transplantation. Patients positive for heparin-induced thrombocytopenia (HIT+ [solid line]) versus control (dashed line). The Annals of Thoracic Surgery 2007 84, 841-846DOI: (10.1016/j.athoracsur.2007.03.049) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions