Product characteristics and pharmacokinetics of intranasal ipratropium bromide Chester C. Wood, MDa, Philip Fireman, MDb, Jay Grossman, MDc, Margaret.

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Presentation transcript:

Product characteristics and pharmacokinetics of intranasal ipratropium bromide Chester C. Wood, MDa, Philip Fireman, MDb, Jay Grossman, MDc, Margaret Wecker, PhDa, Thomas MacGregor, PhDa Journal of Allergy and Clinical Immunology Volume 95, Issue 5, Pages 1111-1116 (May 1995) DOI: 10.1016/S0091-6749(95)70214-8 Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Schematic representation of the chemical structures of ipratropium bromide and atropine. PC7.4 is the octanol-buffer partition coefficient at pH 7.4. Journal of Allergy and Clinical Immunology 1995 95, 1111-1116DOI: (10.1016/S0091-6749(95)70214-8) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Assessment protocol for pharmacokinetic of ipratropium bromide nasal spray (0.06%) with its saline vehicle in healthy volunteers and in the same subjects after infection with human rhinovirus 39. Journal of Allergy and Clinical Immunology 1995 95, 1111-1116DOI: (10.1016/S0091-6749(95)70214-8) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Pupillary measurements after administration of ipratropium bromide (0.03% and 0.06%) and its saline vehicle in healthy volunteers. Journal of Allergy and Clinical Immunology 1995 95, 1111-1116DOI: (10.1016/S0091-6749(95)70214-8) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Pupillary measurements after administration of ipratropium bromide (0.03% and 0.06%) and its saline vehicle in healthy volunteers. Journal of Allergy and Clinical Immunology 1995 95, 1111-1116DOI: (10.1016/S0091-6749(95)70214-8) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Comparison of pupillary measurements after administration of ipratropium bromide (0.06%) and its saline vehicle in healthy volunteers and in the same subjects after infection with rhinovirus 39 (days 3 and 7). Journal of Allergy and Clinical Immunology 1995 95, 1111-1116DOI: (10.1016/S0091-6749(95)70214-8) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Comparison of pupillary measurements after administration of ipratropium bromide (0.06%) and its saline vehicle in healthy volunteers and in the same subjects after infection with rhinovirus 39 (days 3 and 7). Journal of Allergy and Clinical Immunology 1995 95, 1111-1116DOI: (10.1016/S0091-6749(95)70214-8) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Comparison of pupillary measurements after administration of ipratropium bromide (0.06%) and its saline vehicle in healthy volunteers and in the same subjects after infection with rhinovirus 39 (days 3 and 7). Journal of Allergy and Clinical Immunology 1995 95, 1111-1116DOI: (10.1016/S0091-6749(95)70214-8) Copyright © 1995 Mosby, Inc. Terms and Conditions