Does Low PAPP-A Predict Adverse Placenta-Mediated Outcomes in a Low-Risk Nulliparous Population? the Great Obstetrical Syndromes (GOS) Study Amélie Boutin,

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Does Low PAPP-A Predict Adverse Placenta-Mediated Outcomes in a Low-Risk Nulliparous Population? the Great Obstetrical Syndromes (GOS) Study Amélie Boutin, PhD, Cédric Gasse, MD, Suzanne Demers, MD, MSc, Geneviève Blanchet, MD, Yves Giguère, MD, PhD, Emmanuel Bujold, MD, MSc Journal of Obstetrics and Gynaecology Canada Volume 40, Issue 6, Pages 663-668 (June 2018) DOI: 10.1016/j.jogc.2017.08.047 Copyright © 2018 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 1 First trimester maternal PAPP-A according to crown-rump length and its association with pregnancy outcomes. First trimester PAPP-A concentration was lower in cases of SGA (P < 0.05) (A), but not in cases of preeclampsia (B) or fetal death (C). Cases are represented by red dots and curves; controls are shown in blue. Journal of Obstetrics and Gynaecology Canada 2018 40, 663-668DOI: (10.1016/j.jogc.2017.08.047) Copyright © 2018 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 2 Prediction of adverse pregnancy outcomes with first trimester maternal PAPP-A. Receiver operating characteristic curves of first trimester maternal PAPP-A for the prediction of preeclampsia (blue), SGA (green), and fetal death (red). Journal of Obstetrics and Gynaecology Canada 2018 40, 663-668DOI: (10.1016/j.jogc.2017.08.047) Copyright © 2018 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Journal of Obstetrics and Gynaecology Canada 2018 40, 663-668DOI: (10 Journal of Obstetrics and Gynaecology Canada 2018 40, 663-668DOI: (10.1016/j.jogc.2017.08.047) Copyright © 2018 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions