Pulmonary Hypertensive Vasculopathy Following Tandem Autologous Transplantation in Pediatric Patients with Central Nervous System Tumors Tal Schechter,

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Pulmonary Hypertensive Vasculopathy Following Tandem Autologous Transplantation in Pediatric Patients with Central Nervous System Tumors Tal Schechter, Stephan Leucht, Eric Bouffet, Ernest Cutz, Adam Gassas, Annie Huang, Ute Bartels, Tilman Humpl, John Doyle Biology of Blood and Marrow Transplantation Volume 19, Issue 2, Pages 235-239 (February 2013) DOI: 10.1016/j.bbmt.2012.09.011 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Lung biopsy specimen from patient 1 showing well-expanded and relatively well-preserved alveolar spaces (Alv). Three small preacinar pulmonary arteries (PA) show striking luminal narrowing. The pulmonary vein (PV) shows no abnormalities. (Elastic trichrome stain; scale bar: 500 μ.) Biology of Blood and Marrow Transplantation 2013 19, 235-239DOI: (10.1016/j.bbmt.2012.09.011) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Lung biopsy specimen from patient 2 showing focal thickening of the interstitium (asterisk) and obliterative changes affecting small pulmonary artery (PA) branches, with normal-appearing pulmonary veins (PV). (Elastic trichrome stain; scale bar: 500 μ.) (Inset) Higher-magnification view of a pulmonary arteriole showing marked fibrointimal thickening and pinpoint lumen. Media is delineated by elastic laminae (black). (Elastic trichrome stain; scale bar: 50 μ.) Biology of Blood and Marrow Transplantation 2013 19, 235-239DOI: (10.1016/j.bbmt.2012.09.011) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Electron micrograph of alveolar capillary membrane in a lung biopsy specimen from patient 2. The alveolus is lined by cytoplasm of alveolar type 2 cells (Type II) containing osmiophilic lamellar bodies. The alveolar capillary loop shows markedly thickened cytoplasm of endothelial cells (End). The lumen contains RBCs. The alveolar capillary basement membrane is indicated by an arrow; the thin process of alveolar type 1 cells covering alveolar capillaries is indicated by double arrows. (Scale bar: 2 μ.) Biology of Blood and Marrow Transplantation 2013 19, 235-239DOI: (10.1016/j.bbmt.2012.09.011) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions