Pressure elevation slows the fibroblast response to wound healing

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Pressure elevation slows the fibroblast response to wound healing Andrew C. Stanley, MD, Karen M. Lounsbury, PhD, Kim Corrow, AAS, Peter W. Callas, PhD, Rima Zhar, BS, Alan K. Howe, PhD, Michael A. Ricci, MD Journal of Vascular Surgery Volume 42, Issue 3, Pages 546-551 (September 2005) DOI: 10.1016/j.jvs.2005.04.047 Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 1 Images of neonatal fibroblasts (×4) at atmosphere. Confluent cells (A) before wounding and (B) immediately after wounding (arrows delineate wound edge). Journal of Vascular Surgery 2005 42, 546-551DOI: (10.1016/j.jvs.2005.04.047) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 2 Images of neonatal fibroblasts (NNF) (×10) before and after wounding. Shown here are NNF grown to confluence and before wounding at (A) atmosphere (ATM), (B) ATM plus 30 mm Hg, (C) ATM plus 60 mm Hg, and (D) ATM plus 120 mm Hg. NNF 2 days after wounding are shown after growing at (E) ATM, (F) ATM plus 30 mm Hg, (G) ATM plus 60 mm Hg, and (H) ATM plus 120 mm Hg. Journal of Vascular Surgery 2005 42, 546-551DOI: (10.1016/j.jvs.2005.04.047) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 2 Images of neonatal fibroblasts (NNF) (×10) before and after wounding. Shown here are NNF grown to confluence and before wounding at (A) atmosphere (ATM), (B) ATM plus 30 mm Hg, (C) ATM plus 60 mm Hg, and (D) ATM plus 120 mm Hg. NNF 2 days after wounding are shown after growing at (E) ATM, (F) ATM plus 30 mm Hg, (G) ATM plus 60 mm Hg, and (H) ATM plus 120 mm Hg. Journal of Vascular Surgery 2005 42, 546-551DOI: (10.1016/j.jvs.2005.04.047) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 3 Time to complete (gross) wound healing for each experimental group. Journal of Vascular Surgery 2005 42, 546-551DOI: (10.1016/j.jvs.2005.04.047) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions