Predicted residual activity of rilpivirine in HIV-1 infected patients failing therapy including NNRTIs efavirenz or nevirapine K. Theys, R.J. Camacho,

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Presentation transcript:

Predicted residual activity of rilpivirine in HIV-1 infected patients failing therapy including NNRTIs efavirenz or nevirapine K. Theys, R.J. Camacho, P. Gomes, A.M. Vandamme, S.Y. Rhee Clinical Microbiology and Infection Volume 21, Issue 6, Pages 607.e1-607.e8 (June 2015) DOI: 10.1016/j.cmi.2015.02.011 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 Prevalence of mutational patterns affecting rilpivirine susceptibility. RAM, resistance associated mutation (left); mutations affecting rilpivirine susceptibility only when in the specified combination (middle); pRAM, potential resistance associated mutation (right). Prevalence in efavirenz-experienced patients (dark grey), in nevirapine-experienced patients (light grey) and in all patients (horizontal bars). Clinical Microbiology and Infection 2015 21, 607.e1-607.e8DOI: (10.1016/j.cmi.2015.02.011) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 Genotypic resistance scores for rilpivirine in different patient populations. ALL, all patients (n = 1212); EFV, efavirenz-experienced (n = 813); NVP, nevirapine-experienced (n = 399). For each interpretation algorithm, proportion of patients scored as high-level resistant (dark grey), intermediate resistant (grey) and susceptible (light grey). Clinical Microbiology and Infection 2015 21, 607.e1-607.e8DOI: (10.1016/j.cmi.2015.02.011) Copyright © 2015 The Authors Terms and Conditions