Figure 3 Localization of ErbB receptors and ligands within the nephron

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Figure 3 Localization of ErbB receptors and ligands within the nephron Figure 3 | Localization of ErbB receptors and ligands within the nephron. ErbB receptors (black text) and their ligands (grey text) involved in the epidermal growth factor receptor (EGFR) pathway are differentially expressed along the various regions of the nephron in human adult kidneys, including the glomerulus, proximal distal tubule, loop of Henle, distal convoluted tubule and the collecting duct. *HB-EGF expression in rat kidneys. EGF, epidermal growth factor; ENaC, epithelial sodium chanel; HB-EGF, heparin binding EGF-like growth factor; TGF-α, transforming growth factor α; TRPM6, transient potential receptor chanel subfamily member 6. Harskamp, L. R. et al. (2016) The epidermal growth factor receptor pathway in chronic kidney diseases Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.91