Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A Diana A. van der Plaat, MSc, Kim de Jong, PhD, Lies Lahousse,

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Presentation transcript:

Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A Diana A. van der Plaat, MSc, Kim de Jong, PhD, Lies Lahousse, PhD, Alen Faiz, PhD, Judith M. Vonk, PhD, Cleo C. van Diemen, PhD, Ivana Nedeljkovic, MD, Najaf Amin, PhD, Guy G. Brusselle, PhD, Albert Hofman, MD, Corry-Anke Brandsma, PhD, Yohan Bossé, PhD, Don D. Sin, PhD, David C. Nickle, PhD, Cornelia M. van Duijn, PhD, Dirkje S. Postma, MD, H. Marike Boezen, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 2, Pages 533-540 (February 2017) DOI: 10.1016/j.jaci.2016.06.062 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Forest plots showing associations of the 2 replicated SNPs and the GRS with FEV1/FVC (as a percentage) in never-smokers. A, rs1512282 located near HHIP. B, rs6849143 located within an intron of FAM13A. C, GRS, which was created by adding up the number of alleles (risk alleles) for both HHIP and FAM13A SNPs associated with a lower FEV1/FVC. A value of 0 means no risk alleles for both SNPs, and a value of 4 means a subject is carrying all 4 risk alleles of both SNPs. B and 95% CI represent the mean difference in percentage FEV1/FVC for each additional allele relative to the wild-type (adjusted for sex, age, and height). Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Raw data plots of gene expression levels in lung tissue according to genotype for HHIP (100139086_TGI_at, A) and FAM13A (100312038_TGI_at, B). Results were obtained from a meta-analysis using data from 3 cohorts included in the lung tissue database (see the Methods section in this article's Online Repository). The meta-analyzed unadjusted mean and 95% CI are plotted. The genotypes are shown on the x-axis, and the log2 microarray intensity is shown on the y-axis. A forest plot showing the adjusted data of all cohorts separately and the meta-analysis is shown in Fig E7 in this article's Online Repository at www.jacionline.org. Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E7 Journal of Allergy and Clinical Immunology 2017 139, 533-540DOI: (10.1016/j.jaci.2016.06.062) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions