Allele Expression Allele expression not always as simple as dominant alleles overriding recessive ones. Alleles of a single gene may interact together.

Slides:



Advertisements
Similar presentations
Blood Group Notes.
Advertisements

14.3: Inheritance patterns are often more complex than predicted by simple Mendelian genetics The relationship between genotype and phenotype is rarely.
Incomplete dominance This is when neither allele is dominant.
Can heredity follow different rules?
Allele Expression Allele expression not always as simple as dominant alleles overriding recessive ones. Alleles of a single gene may interact together.
Extending Mendelian Genetics The relationship between genotype and phenotype is rarely simple.
Everything you need to know about Genetics
Testcross Dominant phenotype with unknown genotype Recessive phenotype
Genes that are located on the sex chromosomes are sex-linked genes. In mammals, individuals with two X chromosomes, an XX genotype, are females. Individuals.
Chapters 6 and 7; Patterns of Heredity
Genetics Chapter 8.
Non-Mendelian Genetics
Beyond Mendel’s Laws of Inheritance
Complex Inheritance Patterns
GENETIC INHERITANCE.
Complex Patterns of Inheritance
Patterns of Inheritance
Review Questions What is the difference between a genotype and a phenotype? What are the terms for genotypes AA, aa, and Aa? If a red flower (RR) is crossed.
Different inheritance patterns
Non-Mendelian Genetics
Dominant Traits Recessive Traits Freckles No freckles Widow’s peak
Multiple Alleles & Polygenic Traits
Complex Patterns of Inheritance
Complex Patterns of Inheritance
Variations to Mendelian Inheritance
Extensions on Mendelian Genetics
Complex Patterns of Inheritance
Introduction to Genetics
Beyond Mendel.
Genetics Jeopardy!.
Bookend In a heterozygous tall plant, the ____________ trait shows. It is represented by a _________ letter. ( T ) Tt is a tall or short plant. The.
Gregor Mendel's Genetics
Complex Patterns of Inheritance
Patterns of Inheritance
Exceptions to the Rule of Dominance & Recessiveness
Genetics: Beyond Mendel.
Variations of Genetics
Exceptions to Mendelian Genetics
Punnett Squares: Part 2.
Punnett Squares: Part 2.
Beyond Mendel.
Patterns of Heredity.
Non-Mendelian Genetics Honors Biology Ms. Day
Lecture # 6 Date _________
Sex-Linked Punnett Square Notes
Non-Mendelian Genetics
Exceptions to Mendelian Genetics
Mendel and the Gene Idea
Genetics – Types of Inheritance
When Heredity Follows Different Rules
Allele Expression Allele expression not always as simple as dominant alleles overriding recessive ones. Alleles of a single gene may interact together.
Variations to Mendelian Inheritance
Heredity Chapter 12, part 2.
Variations in Heredity
Non-Mendelian Genetics
Gene linkage and polyploidy
Variations of Inheritance Patterns
Non-Mendelian Genetics
Human Genetics Chapter 7
Non-Mendelian Genetics
What if we consider two genes at one time?
Non-Mendelian Genetics
Types of Dominance.
Mendelian Genetics: Dominant & Recessive Review
Non-Mendelian Genetics
Complete Incomplete Codominance Multiple Alleles Sex-linked Traits
Complex Punnett Squares
Mendel’s Dominance Mendel’s rule of dominance was complete dominance
Beyond Dominant and Recessive Alleles
Heredity and Genetic Analysis
Presentation transcript:

Allele Expression Allele expression not always as simple as dominant alleles overriding recessive ones. Alleles of a single gene may interact together and give rise to phenotypes that are dissimilar to both of the parents. This may be because: The genes are sex-linked. Incomplete dominance Codominance Multiple alleles Incomplete dominance in snapdragons produces pink flowers from red and white parents Roan coat color in cattle is a result of codominance between red and white alleles

Incomplete Dominance In cases of incomplete dominance, neither allele dominates and the heterozygote is intermediate in phenotype between the two homozygotes. Examples of incomplete dominance include flower color in snapdragons (right) and sweet peas, where red and white flowered plants cross to produce pink flowered plants. CrCr CrCw CwCw

Flower Color in Snapdragons Red flower White flower Parents CrCr X CwCw Gametes Cr Cw Possible fertilizations Pink F1 offspring CrCw

Example problems (answer by showing Punnet squares): 1. If a white flowered plant is crossed with a red flowered plant, what are the genotypic and phenotypic ratios of the F1? 2. If two of the F1 offspring were crossed, what genotypes and phenotypes ratios would appear in the F2?

Codominance In cases of codominance, both alleles are independently and equally expressed in the heterozygote. Roan (stippled red and white) coat color in cattle. AB human blood groups. Black and tan tabby cats White cow Red bull CRCR CWCW Parents X CR CW Gametes Possible fertilizations Roan CRCW F1 offspring

Example problem 1. Cross two heterozygous (roan) shorthorn cattle X Roan cow Roan bull CRCW Parents X CW CR Gametes Possible fertilizations White Roan Red CRCR CRCW CWCW Offspring

Example Problem 2. A true breeding red parent is crossed with a roan parent X Roan cow Red bull Parents Gametes CW CR CRCR CRCW Possible fertilizations Offspring Roan Red CRCR CRCW

Multiple Alleles in Blood Humans have 4 blood group phenotypes: A, B, AB and O The four common blood groups of the human ABO blood group system are determined by three alleles: IA, IB, i (however any one individual can possess only two alleles) IA & IB are co-dominant and i is recessive.

Blood type IA IA IA i type A IB IB IB i type B IA IB type AB i i genotype phenotype status IA IA IA i type A type A oligosaccharides on surface of RBC __ IB IB IB i type B type B oligosaccharides on surface of RBC IA IB type AB both type A & type B oligosaccharides on surface of RBC universal recipient i i type O no oligosaccharides on surface of RBC universal donor

Multiple Alleles in Blood X Blood group: AB Parent genotypes EXAMPLE 1: Cross two parents, both with AB blood type AB Gametes IB IA Possible fertilizations Children's genotypes IAIB IBIB IAIA B Blood groups AB A

Multiple Alleles in Blood Blood group: B Blood group: A X Parent genotypes EXAMPLE 2: Two parents with blood groups A and B respectively, both heterozygous IBi IAi Gametes i IB IA Possible fertilizations Children's' genotypes IAi ii IBi IAIB A O B Blood groups AB

XY Sex Determination In the XY type, sex determination is based on the presence or absence of the Y chromosome; without it, an individual will develop into a female. XY sex determination occurs in: Mammals (including humans) Fruit fly Drosophila Some dioecious (separate male and female) plants such as kiwifruit. Females are homogametic with two similar sex chromosomes (XX). The male has two unlike chromosomes (XY) and is heterogametic. Primary sex characteristics are initiated by genes on the X. ‘Maleness’ is determined by the Y. Female Male XX XY X Parents X X X Y Gametes Possible fertilizations XX XY XX XY Offspring Sex: Female Male Female Male

Sex Linkage Genes located on the X chromosomes are called X-linked Because the Y chromosome is small and does not contain many genes, few traits are Y- linked and Y-linked diseases are rare. X Y Note the size differences between the X and Y chromosomes. The Y lacks alleles for many of the genes present on the X. http://abcnews.go.com/Primetime/Video/playerIndex?id=2264698

Examples: X-linked traits are denoted XD for a dominant allele and Xd for a recessive allele For most X-linked genes, the dominant form is the healthy form. Hemophilia Xh Normal blood clotting XH Muscular dystrophy Xm Non-muscular dystrophy XM Color blindness Xĉ Non-color blindness XC

A human female can be homozygous or heterozygous with respect to sex-linked genes. Female heterozygous for X-linked alleles are called carriers, because they don’t have the disease (they have one good copy of the gene) but they do “carry” the bad allele. Since (normally) males only have one X chromosome, males only have one copy of genes located on the X chromosome.

Sex Linkage Sex-linked traits show a distinct pattern of inheritance. Fathers pass sex-linked alleles to all their daughters but not to their sons. Mothers can pass sex-linked alleles to both sons and daughters. In females, sex-linked recessive traits will be expressed only in the homozygous condition. In contrast, any male receiving the recessive allele from his mother will express the trait. Carrier mother X X Y Unaffected father Carrier daughter X Affected son X Y Unaffected son Y X Unaffected daughter X

Practice Problems Suppose a color blind man fathers children with a woman of the genotype XC XC. What proportion of daughters would be color blind? What proportion of sons would be color blind? One of the daughters from the above problem marries a color blind man. What proportion of their sons will be color blind?

Pleiotropy Most genes are pleiotropic one gene affects more than one phenotypic character wide-ranging effects due to a single gene: dwarfism (achondroplasia) gigantism (acromegaly) The genes that we have covered so far affect only one phenotypic character, but most genes are pleiotropic

Acromegaly: André the Giant

Pleiotropy It is not surprising that a gene can affect a number of organism’s characteristics consider the intricate molecular & cellular interactions responsible for an organism’s development cystic fibrosis mucus build up in many organs sickle cell anemia sickling of blood cells

Polygenic Inheritance Patterns Traits determined by 2 or more genes

Polygenic inheritance Some phenotypes determined by additive effects of 2 or more genes on a single character phenotypes on a continuum human traits skin color height weight eye color

Prevalence of dominance Because an allele is dominant does not mean… it is better it is more common Polydactyly: dominant allele

Polydactyly individuals are born with extra fingers or toes dominant to the recessive allele for 5 digits recessive allele far more common than dominant  399 individuals out of 400 have only 5 digits  most people are homozygous recessive (aa)

Hound Dog Taylor