1.5 1.0 0.5 KCNA1 a KCNA2 b (relative to control) Fold changes 1.5 1.0

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Figure S3: Effects of METH SA on potassium channel mRNA expression in the pre-frontal cortex 1.5 1.0 0.5 KCNA1 a KCNA2 b (relative to control) Fold changes 1.5 1.0 0.5 2.0 KCNAB1 c KCNB2 d 1.5 1.0 0.5 KCNMA1 e KCNN1 f 2.0 1.5 1.0 0.5 * KCNN3 Control SR SS h KCNN2 g Control SR SS Effects of METH SA on DNA hydroxymethylation and expression of potassium channels in the pre-frontal cortex. ( a-h) mRNA expression of potassium channels in abstinent (SS) and compulsive (SR) METH takers. Key to statistics: * P < 0.05 in comparison to control