Β-Chemokine secretion patterns in relation to clinical course and outcome in children after cardiopulmonary bypass: continuing the search to abrogate.

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β-Chemokine secretion patterns in relation to clinical course and outcome in children after cardiopulmonary bypass: continuing the search to abrogate systemic inflammatory response Danny Lotan, MD, Dorit Zilberman, MD, Ovdi Dagan, MD, Natan Keller, MD, Ron Ben-Abraham, MD, Avi A. Weinbroum, MD, Ran Harel, MD, Zohar Barzilay, MD, Gideon Paret, MD The Annals of Thoracic Surgery Volume 71, Issue 1, Pages 233-237 (January 2001) DOI: 10.1016/S0003-4975(00)02020-8

Fig 1 Changes in the median circulating concentration of monocyte chemoattractant protein-1 (MCP-1; upper panel) and regulated-upon-activation normal T-cell expressed and secreted (RANTES; lower panel) at various times before, during, and after cardiopulmonary bypass. Results are expressed as mean ± standard error of mean. • Significantly different from the preceding time period (p < 0.03). ▵ Significantly different versus induction (p < 0.040). ∗ Significantly different versus induction (p < 0.002). The Annals of Thoracic Surgery 2001 71, 233-237DOI: (10.1016/S0003-4975(00)02020-8)

Fig 2 Changes in the median circulating concentration of monocyte chemoattractant protein-1 (MCP-1; upper panel) and regulated-upon-activation normal T-cell expressed and secreted (RANTES; lower panel) versus time in children undergoing cardiopulmonary bypass: children requiring surgical time more than 200 minutes (n = 7; black bars) versus children requiring surgical time less than 200 minutes (n = 9; open bars). Results are mean ± standard error of mean. ∗p less than 0.02. The Annals of Thoracic Surgery 2001 71, 233-237DOI: (10.1016/S0003-4975(00)02020-8)

Fig 3 Changes in the median circulating concentration of monocyte chemoattractant protein-1 (MCP-1) with time in children undergoing cardiopulmonary bypass: children requiring inotropic support (n = 7; black bars) versus children without inotropic support (n = 9; open bars). Results are mean ± standard error of mean. ∗p less than 0.04. The Annals of Thoracic Surgery 2001 71, 233-237DOI: (10.1016/S0003-4975(00)02020-8)

Fig 4 Changes in the median circulating concentration of monocyte chemoattractant protein-1 (MCP-1; upper panel) and regulated-upon-activation normal T-cell expressed and secreted (RANTES; lower panel) with time in children undergoing cardiopulmonary bypass: children reoperated (n = 4; black bars) versus children not reoperated (n = 12; open bars). Results are mean ± standard error of mean. ∗p less than 0.035. The Annals of Thoracic Surgery 2001 71, 233-237DOI: (10.1016/S0003-4975(00)02020-8)