Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: a Markov model analysis Dr Ana Requena-Méndez,

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Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: a Markov model analysis Dr Ana Requena-Méndez, PhD, Sheila Bussion, Edelweiss Aldasoro, MSc, Yves Jackson, PhD, Andrea Angheben, MD, David Moore, PhD, Maria-Jesús Pinazo, PhD, Joaquim Gascón, PhD, Jose Muñoz, PhD, Elisa Sicuri, PhD The Lancet Global Health Volume 5, Issue 4, Pages e439-e447 (April 2017) DOI: 10.1016/S2214-109X(17)30073-6 Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 1 Decision-tree for Trypanosoma cruzi screening The Lancet Global Health 2017 5, e439-e447DOI: (10.1016/S2214-109X(17)30073-6) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 2 Markov model—number of individuals in each state at each cycle Test option (A), no-test option (B), and detail of number of deaths in the test and no-test option (C). In (C) cycles start at 1 because there are no deaths at cycle 0. The Lancet Global Health 2017 5, e439-e447DOI: (10.1016/S2214-109X(17)30073-6) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 3 Threshold sensitivity analysis of the incremental cost-effectiveness ratio (ICER) Relationship between ICER and Chagas disease prevalence (A); detail of the relationship between ICER and Chagas disease prevalence when disease prevalence is between 0 and 0·5% (B); and relationship between ICER and probability of screen and treat (C). QALY=quality-adjusted life-years. The Lancet Global Health 2017 5, e439-e447DOI: (10.1016/S2214-109X(17)30073-6) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions