Utf1: Goldilocks for ESC Bivalency

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Utf1: Goldilocks for ESC Bivalency Agnieszka I. Laskowski, Paul S. Knoepfler Cell Stem Cell Volume 11, Issue 6, Pages 732-734 (December 2012) DOI: 10.1016/j.stem.2012.11.012 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 A Model Showing Opposing Functions of Utf1 on Bivalent Gene Expression in Pluripotent Stem Cells Yellow circles labeled “BiV” represent bivalent genes. Other factors are presented as indicated with Utf1 in blue, Arf in green, and PRC2 in red. mDc is the mRNA decapping complex. Smaller circles represent mRNAs being degraded. In the balance, decreased BiV levels are reflected by the scale pan going up and being less weighty, while the reverse is the case on the right with increasing BiV levels. Cell Stem Cell 2012 11, 732-734DOI: (10.1016/j.stem.2012.11.012) Copyright © 2012 Elsevier Inc. Terms and Conditions