Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian.

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Presentation transcript:

Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian Ying Li, MD, Zhi Bin Lin, MD, Mei Kee Lim, BSc, Frank McKeon, PhD, Wa Xian, PhD, De Yun Wang, MD, PhD Journal of Allergy and Clinical Immunology Volume 127, Issue 3, Pages 765-772.e2 (March 2011) DOI: 10.1016/j.jaci.2010.12.011 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Expression of p63 and TAp73 protein determined by means of immunohistochemistry in the nasal mucosa of representative control subjects (A), GC-naive patients with NP (B), and GC-treated patients with NP (C). Original magnification ×400. Journal of Allergy and Clinical Immunology 2011 127, 765-772.e2DOI: (10.1016/j.jaci.2010.12.011) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Quantitative determination of mRNA by means of real-time RT-PCR for p63 (A), p73 (B), and the 2 p73 isoforms TAp73 (C) and ΔNp73 (D) in tissues from GC-naive (-GC) patients with NP and control subjects. All target mRNA relative expression levels were given as ratios of GAPDH transcript levels in the same RNA sample. Box plots are shown with medians plus 5th to 95th percentile whiskers. Statistical analyses were performed with the Mann-Whiney 2-tailed test. P values were considered significant at less than .05. Journal of Allergy and Clinical Immunology 2011 127, 765-772.e2DOI: (10.1016/j.jaci.2010.12.011) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Relationship between mRNA levels of p63 versus p73 (A), TAp73 (B), and ΔNp73 (C) and mRNA levels between TAp73 and ΔNp73 (D) in GC-naive patients with NP and control subjects. The correlation coefficient (r) was calculated by using Spearman rank analysis. Journal of Allergy and Clinical Immunology 2011 127, 765-772.e2DOI: (10.1016/j.jaci.2010.12.011) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Quantitative determination of mRNA by means of real-time RT-PCR for p63 (A), p73 (B), and the 2 p73 isoforms TAp73 (C) and ΔNp73 (D) in GC-naive (-GC) and GC-treated (+GC) patients with NP. All target mRNA relative expression levels were given as ratios of GAPDH transcript levels in the same RNA sample. Connecting lines indicate data obtained in the same subject before and after GC treatment. Statistical analyses were performed with the Wilcoxon matched-pairs signed-rank test. P values were considered significant at less than .05. NS, Not significantly different. Journal of Allergy and Clinical Immunology 2011 127, 765-772.e2DOI: (10.1016/j.jaci.2010.12.011) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 A list of known p63-related biological functions and diseases by using IPA. Fx, Functions and diseases. Journal of Allergy and Clinical Immunology 2011 127, 765-772.e2DOI: (10.1016/j.jaci.2010.12.011) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions