Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis William R Kessler, Oscar W Cummings, George Eckert, Naga Chalasani,

Slides:

Advertisements

Similar presentations

Dr Ian Chandler February 2013

Advertisements

Hepatobiliary system Integrated practical

Genetic testing for high-risk colon cancer patients1 William M. Grady Gastroenterology Volume 124, Issue 6, Pages (May 2003) DOI: /S (03)

Celiac Disease Genetics: Current Concepts and Practical Applications Ludvig M. Sollid, Benedicte A. Lie Clinical Gastroenterology and Hepatology Volume.

Acute viral hepatitis There is disruption of lobular architecture, inflammatory cells in the portal tracts & sinusoids, and hepatocellular apoptosis (arrow).

Case Report AK Liver biopsy total length 6 mm suggestiv for

Patterns of Hepatic Injury

Optimizing Diagnosis From the Medical Liver Biopsy

Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis

The role of Epstein–Barr virus in acute and chronic hepatitis

Chapter 12 Liver Transplantation 1

Chapter 12 Liver Transplantation 1

Volume 139, Issue 1, Pages (July 2010)

Hepatitis induced by Kava (Piper methysticum rhizoma)

Incorrect Calculation and Inappropriate Interpretation: Accuracy of International Guidelines for Identifying Significant Fibrosis in e Antigen–Negative.

Acute hepatitis induced by greater celandine (Chelidonium majus)

Kester Crosse, Onuora G. Umeadi, Frank A

Chronic viral hepatitis type B and chronic delta

Ghazaleh Aram, Theodore M. Bayless, Zong–Ming Chen, Elizabeth A

Gastrointestinal Involvement in Polyarteritis Nodosa

The Use of Immunoglobulin G4 Immunostaining in Diagnosing Pancreatic and Extrapancreatic Involvement in Autoimmune Pancreatitis Maesha G. Deheragoda,

Naveen B. Krishna, Laura Gardner, Brian T. Collins, Banke Agarwal

The Use of Immunoglobulin G4 Immunostaining in Diagnosing Pancreatic and Extrapancreatic Involvement in Autoimmune Pancreatitis Maesha G. Deheragoda,

Serologic Markers Do Not Predict Histologic Severity or Response to Treatment in Patients With Autoimmune Hepatitis Vaibhav Mehendiratta, Pradnya Mitroo,

Management of Dyslipidemia as a Cardiovascular Risk Factor in Individuals With Nonalcoholic Fatty Liver Disease Kathleen E. Corey, Naga Chalasani Clinical.

Hepatitis B virus infection: Current status

Optimizing Diagnosis From the Medical Liver Biopsy

The role of Epstein–Barr virus in acute and chronic hepatitis

Kevin O’Brien, Nadeem Hussain, Bradley A. Warady, David E

Maya Srivastava, Antonio Perez–Atayde, Maureen M. Jonas

Diagnosing autoimmune hepatitis in children: Is the International Autoimmune Hepatitis Group scoring system useful? Regan L. Ebbeson, Richard A. Schreiber

Genetics of Colonic Polyposis

Combination therapy with lamivudine and famciclovir for chronic hepatitis B infection Hong Shen, Mazen Alsatie, George Eckert, Naga Chalasani, Lawrence.

What is the long-term outcome of the liver allograft?

Volume 141, Issue 5, Pages e9 (November 2011)

Ian R. Gooding, Roger Springall, Ian C. Talbot, David B.A. Silk

Interpreting Hepatitis B Surface Antigen Levels: Useful Clinical Test or Just Another Confusing Assay? Brian J. McMahon, MD, Brenna C. Simons, PhD Clinical.

Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency Raz Somech, MD,

A. James Hanje, Lindsay J. Pell, Nicholas A. Votolato, Wendy L

Anouk Dev, Keyur Patel, Andrew Conrad, Lawrence M. Blatt, John G

Adequacy of Endoscopic Ultrasound Core Needle Biopsy Specimen of Nonmalignant Hepatic Parenchymal Disease Ferga C. Gleeson, Amy C. Clayton, Lizhi Zhang,

Severe Constipation Clinical Gastroenterology and Hepatology

De novo autoimmune hepatitis after liver transplantation

William D. Leslie Clinical Gastroenterology and Hepatology

Mallory–Denk Bodies Are Associated With Outcomes and Histologic Features in Patients With Chronic Hepatitis C Mina O. Rakoski, Morton B. Brown, Robert.

Volume 150, Issue 2, Pages e3 (February 2016)

Volume 39, Issue 5, Pages (November 2003)

Clinical and Histologic Features of Azithromycin-Induced Liver Injury

Severe Hepatic Side Effects of Ezetimibe

Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis

Volume 129, Issue 1, Pages (July 2005)

David H. Bruining, William J. Sandborn

Volume 142, Issue 5, Pages e1 (May 2012)

Sharon J. Hutchinson, Sheila M. Bird, David J. Goldberg

Nonalcoholic Steatohepatitis

Pathologic features of interstitial nephritis associated with inflammatory bowel disease. Pathologic features of interstitial nephritis associated with.

Idiopathic tumefactive chronic pancreatitis: Clinical profile, histology, and natural history after resection Dhiraj Yadav, Kenji Notahara, Thomas C.

Severe autoimmune hepatitis first presenting in the early post partum period Douglas Samuel, Stephen Riordan, Simone Strasser, Jelica Kurtovic, Indira.

Progression of fibrosis in chronic hepatitis C

Volume 50, Issue 3, Pages (March 2009)

Alan Bonder, MD, Nezam H. Afdhal, MD

Chronic Diarrhea Clinical Gastroenterology and Hepatology

Volume 62, Issue 3, Pages (March 2015)

Julia Lörke, Andreas Erhardt, Dieter Häussinger

Volume 139, Issue 1, Pages (July 2010)

Controversies in the management of hepatitis C patients with advanced fibrosis and cirrhosis Robert J Fontana, Gregory T Everson, Sony Tuteja, Hugo E.

Scott K. Fung, Anna S.F. Lok Clinical Gastroenterology and Hepatology

Shradha Agarwal, Lloyd Mayer Clinical Gastroenterology and Hepatology

Fulminant Hepatic Failure Secondary to Erlotinib

Top left—H&E stain showing acute hepatitis with lobular disarray and associated lymphocytic inflammation, acidophil body formation (arrow) and bilirubinostasis.

Presentation transcript:

Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis William R Kessler, Oscar W Cummings, George Eckert, Naga Chalasani, Lawrence Lumeng, Paul Y Kwo Clinical Gastroenterology and Hepatology Volume 2, Issue 7, Pages 625-631 (July 2004) DOI: 10.1016/S1542-3565(04)00246-0

Figure 1 Acute autoimmune hepatitis. (A and B) There is marked zone 3 hepatocyte necrosis and collapse associated with a mixed chronic inflammatory cell infiltrate including eosinophils, plasma cells and lymphocytes. (C) The portal tract (right hand corner) shows no inflammation or fibrosis (trichrome stain). Clinical Gastroenterology and Hepatology 2004 2, 625-631DOI: (10.1016/S1542-3565(04)00246-0)

Figure 2 Chronic autoimmune hepatitis. The portal tract is predominantly expanded by a chronic inflammatory cell infiltrate. (A) There is an interface hepatitis (B) with small buds of type-one collagen extending into the lobule (periportal fibrosis). Clinical Gastroenterology and Hepatology 2004 2, 625-631DOI: (10.1016/S1542-3565(04)00246-0)