Insight into Binding of Calyculin A to Protein Phosphatase 1

Slides:



Advertisements
Similar presentations
Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
Advertisements

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
Inhibitor Binding Increases the Mechanical Stability of Staphylococcal Nuclease Chien-Chung Wang, Tian-Yow Tsong, Yau-Heiu Hsu, Piotr E. Marszalek Biophysical.
Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
A Hydrodynamic Model for Hindered Diffusion of Proteins and Micelles in Hydrogels Ronald J. Phillips Biophysical Journal Volume 79, Issue 6, Pages
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.
Cultured Schwann Cells Constitutively Express the Myelin Protein P0 Lili Cheng, Anne W Mudge Neuron Volume 16, Issue 2, Pages (February 1996) DOI:
LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions Takayuki Miki, Sho-hei Fujishima, Kazuhiro.
Codon usage limitation in the expression of HIV-1 envelope glycoprotein Jürgen Haas, Eun-Chung Park, Brian Seed Current Biology Volume 6, Issue 3, Pages.
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.
Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis Tzumin Lee, Liqun Luo Neuron Volume 22, Issue 3,
2002 Air Medical Transport Industry Awards Air Medical Journal Volume 22, Issue 2, Pages (March 2003) DOI: /S X(03) Copyright.
Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.
Nucleosomes and Cisplatin
Volume 22, Issue 5, Pages v-vi (May 2015)
Volume 8, Issue 9, Pages R177-R185 (September 2000)
Enzyme Annotation with Chemical Tools
New Light on Methylthiolation Reactions
Nucleosomes and Cisplatin
On-Bead Library Screening Made Easier
Antibiotics: A New Hope
Foundations for Directed Alkaloid Biosynthesis
Green-Red Flashers to Accelerate Biology
Scratch n’ Screen for Inhibitors of Cell Migration
Chemical Proteomics of Host-Pathogen Interaction
Matthieu Desroses, Mikael Altun  Cell Chemical Biology 
Prediction of protein structure
Adding Specificity to Artificial Transcription Activators
Integrative Cell Biology: Katanin at the Crossroads
Finding the Missing Code of RNA Recognition by PUF Proteins
Volume 9, Issue 7, Pages (July 2002)
Aptamers Meet Allostery
JAK3 Specific Kinase Inhibitors: When Specificity Is Not Enough
Targeting the Undruggable Proteome: The Small Molecules of My Dreams
New Probes for Microtubule Dynamics
DNA-Cation Interactions
Detection of Activated, TIMP-free MMPs
No Need To Be Pure: Mix the Cultures!
A Trojan Horse for Human Immunodeficiency Virus
Building a Metal Binding Domain, One Half at a Time
Activity-Based Profiling for Drug Discovery
Aptamer Structures Chemistry & Biology
Volume 24, Issue 7, Pages R262-R263 (March 2014)
HAT Trick: p300, Small Molecule, Inhibitor
Resisting resistance: new chemical strategies for battling superbugs
PARP Inhibitors: Staying on Target?
Making a New Turn In Matrix Metalloprotease Inhibition
Antigen-Presenting Cells: Professionals and amateurs
Volume 21, Issue 8, Pages v-vi (August 2014)
Foundations for Directed Alkaloid Biosynthesis
A Quick Diversity-Oriented Amide-Forming Reaction to Optimize P-Subsite Residues of HIV Protease Inhibitors  Ashraf Brik, Ying-Chuan Lin, John Elder,
Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets  Andrew T. Krueger, Eric T. Kool  Chemistry.
Keep the motor running Current Biology
L-DOPA Ropes in tRNAPhe
Volume 7, Issue 6, Pages R147-R151 (June 2000)
Volume 21, Issue 9, Pages (September 2014)
Urea Transporter Inhibitors: En Route to New Diuretics
Centrosomes: PIDDosome Joins the Counting Game
Inadequate colonoscopy preparation: Is it time to send out an SMS?
Tools to Tackle Protein Acetylation
Sticking It to Cancer with Molecular Glue for SHP2
Volume 19, Issue 20, Pages R922-R923 (November 2009)
Neoglycopeptides as Inhibitors of Oligosaccharyl Transferase
Volume 4, Issue 3, Pages (March 2018)
Volume 13, Issue 6, Pages (June 2006)
New insights into coral reef threats
Volume 21, Issue 9, Pages (September 2014)
Volume 18, Issue 5, Pages R198-R202 (March 2008)
Volume 22, Issue 4, Pages vii-viii (April 2015)
Presentation transcript:

Insight into Binding of Calyculin A to Protein Phosphatase 1 Toshiyuki Wakimoto, Shigeki Matsunaga, Akira Takai, Nobuhiro Fusetani  Chemistry & Biology  Volume 9, Issue 3, Pages 309-319 (March 2002) DOI: 10.1016/S1074-5521(02)00118-7

Figure 1 Structures of Protein Phosphatase Inhibitors Chemistry & Biology 2002 9, 309-319DOI: (10.1016/S1074-5521(02)00118-7)

Figure 2 Preparation of 9 from Calyculin A (4) and Hemicalyculin A (5) Chemistry & Biology 2002 9, 309-319DOI: (10.1016/S1074-5521(02)00118-7)