David J. Cousins, PhD, Joanne McDonald, BSc, Tak H. Lee, MD, ScD

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Presentation transcript:

Therapeutic approaches for control of transcription factors in allergic disease David J. Cousins, PhD, Joanne McDonald, BSc, Tak H. Lee, MD, ScD Journal of Allergy and Clinical Immunology Volume 121, Issue 4, Pages 803-809 (April 2008) DOI: 10.1016/j.jaci.2008.02.008 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Transcription factor signaling pathways in allergic disease. A schematic diagram detailing the signaling pathways and the points at which therapeutic interventions have been targeted is shown. Thin lines represent steps in the signaling cascade. Thick lines represent therapeutic strategies that have been examined to date. Please refer to the text for detailed descriptions. TCR, T-cell receptor; AS-ODN, antisense oligodeoxynucleotide; NBD, NF-κB essential modulator binding domain; Hsp, heat shock protein; p65/p50, subunits of NF-κB. Journal of Allergy and Clinical Immunology 2008 121, 803-809DOI: (10.1016/j.jaci.2008.02.008) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions