With Happyhour, Everyone's Under the Table

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With Happyhour, Everyone's Under the Table Mark T. Palfreyman Cell Volume 137, Issue 5, Pages 802-804 (May 2009) DOI: 10.1016/j.cell.2009.05.016 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 The Last Fly Left Standing The hppy gene in flies encodes a Ste20 family kinase called Happyhour, which antagonizes the epidermal growth factor receptor/extracellular signal-regulated kinase (EGFR/ERK) pathway. Decreased Happyhour activity and increased signaling via the EGFR/ERK pathway (left) results in resistance to the sedating effects of ethanol, whereas increased Happyhour activity and decreased EGFR/ERK signaling results in hypersensitivity to ethanol (right). Cell 2009 137, 802-804DOI: (10.1016/j.cell.2009.05.016) Copyright © 2009 Elsevier Inc. Terms and Conditions